高强度聚焦超声联合肝动脉化疗栓塞治疗门静脉癌栓的临床研究  

作　　者：黄耀[1] 张卫星[1] 魏杨辉[1] 陈小珍[1] 

机构地区：[1]广东医学院附属深圳福田医院肝胆外科,518000

出　　处：《浙江临床医学》2009年第10期1028-1030,共3页Zhejiang Clinical Medical Journal

摘　　要：目的 探讨高强度聚焦超声（HIFU）联合肝动脉化疗栓塞（TACE）治疗门静脉癌栓（PVTT）的安全性和有效性。方法将42例原发性肝癌（HCC）合并门静脉癌栓（PVTT）患者分为两组，A组（22例）采用HIFU联合TACE进行治疗，B组（20例）单纯采用TACE治疗。结果HIFU联合TACE组治疗后PVTT有5例消失，12例缩小，比TACE组疗效明显（P〈0．05）。HIFU联合TACE组，有11例患者恢复门静脉血流，癌栓内血供较单纯TACE治疗组明显减少（P〈0．05）。联合治疗组中位生存期13．8个月，较同期TACE组中位生存期7．9个月明显延长（P〈0．05）。结论HIFU联合TACE治疗PVTT是一种新的安全、有效、微创的治疗方法，能明显提高患者生活质量，延长寿命。Objective To investigate the safety and efficacy of high intensity focused ultrasound combing with transcatheter arterial chemoembolization in the treatment of portal venous tumor thrombosis. Methods 42 cases of hepatocellular carcinoma with portal venous tumor thrombus were divided into two groups： high intensity focused ultrasound combing with transcatheter arterial chemoembolization group （ group A, n = 22 ）, only transcatheter arterial ehemoembolization group （ group B, n = 20）. Results After being treated by high intensity focused ultrasound combing with transcatheter arterial chemoembolization, embolus disappearing happened in 5 cases; embolus shrinking happened in 12 cases. It was much better than the group of transcatheter arterial ehemoembolization（P〈0. 05）. In group A, blood recanalization happened in 11 eases, the blood flow in the tumor thrombus reduced more remarkable than that in group B （ P 〈 0. 05 ）. The median survival time of group A was 13.8 months, significantly longer than, that of group B, which was 7.9 months （ P 〈 0.05 ）. Conclusions High intensity focused ultrasound combing with transeatheter arterial chemoembolization is a new safe, effective and minimally invasive treatment, which could improve living quality and prolong life markedly.

关 键 词：高强度聚焦超声(HIFU) 肝动脉化疗栓塞(TACE) 门静脉癌栓(PVTT) 

分 类 号：R735.7[医药卫生—肿瘤] R730.5[医药卫生—临床医学]