高Hcy在缺血性脑血管病中的临床意义  

The clinical significance of high homocysteine in ischemic cerebrovascular diseases

作　　者：韩英[1] 施晓芸[1] 

机构地区：[1]福建医科大学附属协和医院干部病房,350001

出　　处：《中国老年保健医学》2009年第5期13-14,共2页Chinese Journal of Geriatric Care

摘　　要：目的观察探讨缺血性脑血管病患者血同型半胱氨酸(Hcy)水平与颈动脉粥样硬化(CAAs)程度的关系,探讨Hcy在缺血性脑血管病中的临床意义。方法对108名缺血性脑血管病患者以血管超声检查双侧颈总动脉、颈内动脉,按照颈动脉斑块大小分为A、B两组;取空腹静脉血,测定胆固醇、甘油三酯、血糖、纤维蛋白原、叶酸、VitB12及Hcy水平,对Hcy水平与CAAs、叶酸、VitB12及其他因素进行相关分析。结果随着CAAs程度的加重,Hcy水平升高,两组之间存在统计学差异(P<0.01);统计学分析表明Hcy与叶酸、VitB12水平呈负相关(P<0.05),叶酸、VitB12水平随CCAs的加重而降低。结论高Hcy血症是CAAs的一个重要的危险因素,是缺血性脑血管病的独立危险因素。Objective To observe the relationship between blood homocysteine （Hcy） levels and carotid atherosclerosis Sclerosis （CAAs） in patients with ischemic cerebrovascular disease ,explore the clinical significance of Hcy in ischemic cerebrovascular diseases. Methods Applicating vascular uhrasonography we examinated bilateral common carotid artery,internal carotid artery of 108 patients with ischemic cerebrovascular disease,and the patients was divided into A,B groups according to the size of carotid artery plaque ;We also determined the cholesterol,triglycerides,blood glucose,fibrinogen, folate,VitB12 and Hcy levels of fasting venous blood, analyzed the relationship between the Hcy levels and CAAs,folic acid, VitB12 and other factors. Results With the degree of CAAs heavier the Hcy levels increased,there is significant difference between the two groups （P〈0.01）;Statistical analysis showed negatively correlation between the Hcy and folate,VitB12 levels （P〈0.05）, at the same time with the degree of CAAs heavier the folate,VitB12 levels reduced. Conclusion High Hcy hyperlipidemia is an important risk factor for CAAs,and is an independent risk factor for ischemic cerebrovascular diseases.

关 键 词：同型半胱氨酸 动脉粥样硬化 缺血性脑血管病 

分 类 号：R743.3[医药卫生—神经病学与精神病学]