顺铂微球选择性动脉栓塞术治疗恶性肿瘤的实验研究及临床应用  

Experimental and Clinical Study on Intraarterial Embolization with Cisplatin Microspheres in Treatment of Malignant Tumor

作　　者：敖国昆[1,2,3] 张毅军[1,2,3] 廖国清 贾树林[1,2,3] 周建平 张军芝[1,2,3] 王红梅 邢军芬 刘无非[1,2,3] 

机构地区：[1]中国人民解放军309医院 [2]新疆临床药物研究所 [3]兰州军区总医院

出　　处：《中国肿瘤临床》1998年第10期706-710,共5页Chinese Journal of Clinical Oncology

基　　金：部级科研基金

摘　　要：目的：研制出抗癌性缓释性栓塞制剂并初步观察临床疗效。方法：采用乙基纤维素包裹顺铂及硫酸钡制成微球。测定微球形态及缓释率。动物实验对顺铂微球的栓塞、缓释作用及毒性进行了观察。临床应用８例。结果：顺铂微球为规则球形，粒径为２００±５０μｍ，具有缓释性。动物实验表明微球注入后犬肝肾发生广泛坏死，微球可缓释出顺铂并且全身毒性小，临床应用疗效满意。结论：顺铂微球通过栓塞和缓释抗癌药物具有较强的抗癌作用，且副作用小，是较为理想的化学性栓塞制剂。Purpose:Preparation of a slow releasing anticancer agents in microspheres at embolization treatment for malignant tumors. Methods:Cisplatin and barium sulfate microspheres encased in ethylcellulose were prepared and its shape and releasing rate were determined. The embolization,releasing and toxic effects were observed in animal experiment. Eight cases of leukemia were treated clinically with embolization of cisplatin microspheres.Results:The CDDP microspheres produced were essentially spherical in shape with a diameter of 200±50μm and good releasing effect. Diffuse hepatic and renal necrosis were observed in animal experiment after infusion of CDDP microspheres. Cisplatin released steadily from the spheres with minimal systemic toxicity.Satisfactory clinical effect was achieved. Conclusion: CDDP microsphere embolization releases anticancer agents slowly with quite strong anticancer effect but minimal toxicity. Thus,it is an ideal chemotherapeutic embolizing preparation in the treatment of tumors.

关 键 词：顺铂微球 恶性肿瘤 肿瘤 药物疗法 

分 类 号：R730.53[医药卫生—肿瘤]