红细胞促肺癌患者外周血NK细胞活性的研究  

Activation of Natural Killer's Cytotoxicity by Erythrocytes in Lung Cancer Patients

作　　者：郭睿[1,2] 郎旭宇[1,2] 宋玉兰 

机构地区：[1]山西医科大学细胞生物学教研室 [2]山西省煤炭中心医院心胸外科

出　　处：《中国肿瘤临床》1998年第10期719-721,共3页Chinese Journal of Clinical Oncology

摘　　要：采用３Ｈ－ＴｄＲ释放法分别检测了单纯ＮＫ细胞活性及红细胞作用下ＮＫ细胞的活性，结果显示肺癌患者外周血ＮＫ细胞活性（２３．７８％±６．３４％）较正常对照组（４１．３７％±７．４３％）明显降低（Ｐ＜０．００５），但在正常人红细胞作用下，其ＮＫ细胞毒活性为３０．３０％±６．５６％，经配对设计ｔ检验有显著性差异（Ｐ＜０．００１）；在肺癌患者红细胞作用下，机体ＮＫ细胞活性无明显变化，经检验不存在显著性差异（Ｐ＞０．０５）。表明正常人红细胞对自身及肺癌患者的ＮＫ细胞活性均有显著的促进作用，在肿瘤免疫学及临床肿瘤的治疗方面将有积极的意义。In order to investigate the activity of normal erythrocytes on natural killer cells in peripheral blood of patients with lung cnacer, we used a 3H Thymidine release assay to measure natural killer mediated cytotoxicity before and after being precoated with cystosol of erythrocytes. The study demonstrated that activity of natural killer cells in patients (23.78±6.34%) ( P <0.005) was significantly lower than that of normal controls (41.37± 7.43%) .However, it could be greatly enhanced (30.30±8.58%) by normal erythrocytes ( P <0.001). Erythrocytes of patients with lung cancer had no effect on natural natural killer cytolysis ( P >0.05). These results indicated that normal erythrocytes could augment activity of natural killer cells both of autochthon and of patients with lung cancer which probably play and important role in tumor immunology.

关 键 词：肺肿瘤 外周血 NK细胞 红细胞 

分 类 号：R734.2[医药卫生—肿瘤]