5-羟色胺对大鼠下丘脑脑薄片视交叉上核神经元昼夜节律性电活动的影响  

Influence of 5-HT on Circadian Electroactivity of Rat Suprachiasmatic Nucleus Neurons in Hypothalamic Slice

作　　者：刘运林[1] 俞光第[1] 蒋星红[1] 印其章[1] 

机构地区：[1]苏州医学院神经生物学研究室,215007

出　　处：《苏州医学院学报》1998年第9期897-900,共4页Acta Academiae Medicinae Suzhou

基　　金：国家自然科学基金!39470240

摘　　要：采用脑薄片方法，观察损毁中缝背核（DR）、不同光照条件、5-羟色胺（5－HT）、氯氮平和利坦色林对视交叉上核（SCN）神经元昼夜自发放电的影响。结果：①SCN有昼高夜低的自发放电的节律性；②5－HT对SCN神经元自发放电有抑制作用，SCN神经元对5－HT的敏感性呈昼低夜高的节律（P＜0.01）；③氯氮平和利坦色林均能阻断5－HT对SCN神经元自发放电的抑制作用；④损毁DR后，SCN神经元对5－HT的敏感性增高，结果提示5－HT7样受体可能参与DR的5－HT能纤维对SCN神经元的调节作用。The influence of serotonin(5 - HT)、 clozapine、ritanserin and dorsal raphe nucleus(DR) Iesion on spontaneous firing of SCN neurons under various illumination conditions was examined using a hypothalamic slice preparation. It was found that:①SCN neurons persist circadian rhythm in spontaneous discharge. The firing rate of SCN neurons is high during subjective day and low during subjective night.②5 - HT inhibits the spontaneous firing of SCN neurons and its sensitivity to 5 - HT in subjective day is lower than that in subjective night(p<0.01 ).③Both clozapine and ritanserin can block the effect of 5 - HT.④The sensitivity of SCN neurons to 5 - HT is higher after DR lesion. The results suggested that the inhibitary effect of 5 - HT proection form DR on SCN neuron discharge might be mediated by 5 - HT7, like receptor.

关 键 词：视交叉上核 5-羟色胺 神经元 昼夜节律 

分 类 号：R338[医药卫生—人体生理学]