污灌玉米有机提取物致小鼠肝肾氧化损伤作用  

Organic pollutants-induced hepatic and renal oxidative damage in mice

作　　者：高红霞[1] 刘英莉[1] 阎红[1] 陈刚[1] 郑国颖[1] 常玉荣 

机构地区：[1]华北煤炭医学院河北省煤矿卫生与安全实验室/华北煤炭医学院预防医学系,河北唐山063000

出　　处：《中国公共卫生》2009年第11期1301-1302,共2页Chinese Journal of Public Health

基　　金：河北省科学技术与发展项目(062761594);河北省教育厅科学研究计划项目(2007316)

摘　　要：目的研究某污灌区玉米中有机污染物对小鼠肝肾组织的氧化损伤作用。方法采用超声振荡法提取某污灌区农田生产的玉米中的有机污染物,对小鼠进行灌胃染毒2周;测定肝、肾组织的总超氧化物歧化酶(T-SOD)、丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-Px)。结果污灌区低、高剂量组肝组织的T-SOD活性分别为(32.44±7.93),(30.92±9.29)U/(mg.prot);肾组织的GSH-PX活性分别为(67.28±27.21),(66.52±15.19)U/(mg.prot),与对照组比较均明显降低(P<0.05或P<0.01)。结论该污灌区玉米有机提取物中含有致小鼠肝肾组织氧化损伤的有机污染物;对照区玉米中的有机污染物很可能来源于被污染的大气。Objective To study hepatic and renal oxidative damage in mice exposed to organic extraction of maize from sewage irrigation area.Methods Organic extractions were obtained from maize collected in pollution area and contol area with supersonic method.Fifty mice were lavaged with the extractions once a day for 14 days and then the contents of malonaldehyde（MDA）,total superoxide dismutase（T-SOD）,glutathione-peroxide（GSH-Px） in liver and kidney tissues of the mice were determined.Results Compared with the reagent control group, T-SOD and GSH-Px in the liver weredecreased in the high-dose group （ P 〈 0. 01 ） ; T-SOD of the kidney were decreased. T-SOD, GHP-Px of the liver were decreased in the mice of high-dose group （ P 〈 0. 05 ）. Conclusion Organic extraction from maize from sewage irrigation area could induce hepatic and renal oxidative damage in mice.

关 键 词：农产品 有机污染物 肝组织 肾组织 氧化损伤 

分 类 号：R575.1[医药卫生—消化系统]