A型肉毒毒素局部注射治疗发作期偏头痛的临床疗效分析  

Therapeutic Effect of Local Injection of BTX-A on the Period of Onset of Migraine

作　　者：汪保华[1] 吕志华[1] 陈斌[1] 黄家彬[1] 连韩[1] 

机构地区：[1]湖北省荆门市第一人民医院神经内科,431800

出　　处：《中国临床实用医学》2009年第11期11-12,共2页China Clinical Practical Medicine

基　　金：湖北省荆门市科技计划项目（项目编号：2007AS0041）

摘　　要：目的 分析A型肉毒毒素治疗发作期偏头痛的临床效果。方法60例偏头痛患者被随机分为对照组（M）和治疗组（C），对照组给予尼莫地平片，治疗组给予A型肉毒毒素，30d后观察临床疗效。结果对照组和治疗组的总有效率分别为76．7％和96．7％（P〈0．05）；治疗组疼痛发作时间减少和伴随症状（眩晕、耳鸣、异物感）人数明显减少，与对照组差异有极显著性（P〈0．01）。结论A型肉毒毒素治疗偏头痛发作期有明显的临床疗效。Objective To observe the clinical effects of BTX-A on the period of onset of migraine. Methods Sixty patients with migraine attacks were randomly divided into treatment group （C） and control group （M）. Patients in eontrol group （M） were given nimodipine tablets, and patients in treatment group were given BTX-A, changes of clinical effect were observed after 30 days. Results Total effective rates in control group and treatment group were 76.7% and 96.7% , respectively（ P 〈 0.05 ）. The pain onset time reduced and the numbers of the eases with the simultaneous phenomena of dizziness, tinnitus and foreign body sensation deereased significantly （ P 〈 0. 01 ）. Conclusion BTX-A has a significant therapeutic effect on the period of onset of migraine.

关 键 词：A型肉毒毒素 偏头痛 发作期 疗效分析 

分 类 号：R74[医药卫生—神经病学与精神病学]