首发抑郁症患者治疗前后高兴体验的fMRI改变  

Neural responses with happy emotional processing of patients with first-onset major depressive disorder by antidepressant treatment investigated with functional MRI

作　　者：孙军[1,2] 刘含秋[1] 冯晓源[1] 郭琴[3] 施慎逊[3] 

机构地区：[1]复旦大学附属华山医院放射科,上海200040 [2]南京医科大学附属南京第一医院放谢科,江苏南京210006 [3]复旦大学附属华山医院精神科,上海200040

出　　处：《南京医科大学学报（自然科学版）》2009年第11期1554-1559,共6页Journal of Nanjing Medical University(Natural Sciences)

基　　金：上海市科委科技攻关项目(064119535);上海市功能磁共振成像重点实验室开放课题基金(FMRI061201)

摘　　要：目的:应用功能磁共振(fMRI)技术,探讨首发抑郁症患者药物治疗前后体验高兴表情的脑功能区变化特点。方法:采用3.0T磁共振,对13例首发抑郁症患者(分别于抗抑郁药物治疗前及治疗8周后)和14例性别、年龄相匹配的正常志愿者进行fMRI检查。运用SPM2分析软件,比较体验高兴表情(与中性表情对照)的脑功能区变化。结果:高兴体验时,治疗前患者组左侧额上、中回背外侧皮层活动性较正常人减低(P<0.001,uncorrected),经过治疗后恢复(P<0.001,uncorrected)。结论:高兴体验的fMRI可以作为一项客观评价抗抑郁药物疗效的生物学指标。Objectlve：To detect changes of neural response on happy facial expressions in first-onset major depressive disorder （MDD）by antidepressant treatment investigated with functional magnetic resonance imaging （fMRI）. Methods：Thirteen patients with first onset MDD and 14 normal age-matched volunteers underwent fMRI and patients underwent scanning twice during an 8-week period. Blood oxygenation level dependent（BOLD） was processed using SPM2 to compare the function of whole brain between the two groups exposure to neutral and positive pictures. Results： Decreased activation of left laterial superior frontal cortex exposure to happy pictures was found in patients compared with control group （P 〈 0.001 ,uncorrected）. Symptomatic improvement after antidepressant was associated with reversion of left laterial superior frontal cortex （P 〈 0.001 ,uncorrected）. Conclusion： Changes in BOLD offMRI associated with symptomatic improvement indicate that fMRI may be a useful marker of antidepressant treatment response.

关 键 词：抑郁症 药物治疗 功能磁共振成像 高兴 

分 类 号：R749.4[医药卫生—神经病学与精神病学]