复方甘草酸苷联合川芎嗪治疗酒精性肝病的疗效观察  

Observation of curative effects of compound glycyrrhizin combined with ligustrazine on patients with alcoholic liver disease

作　　者：韩俊岭[1] 韩莹[2] 张春艳[1] 李朝晖[1] 曲磊红[1] 李莉[1] 郑岳[1] 

机构地区：[1]秦皇岛市第一医院消化内科,河北秦皇岛066002 [2]秦皇岛港口医院检验科,河北秦皇岛066002

出　　处：《南京医科大学学报（自然科学版）》2009年第11期1607-1610,共4页Journal of Nanjing Medical University(Natural Sciences)

摘　　要：目的:观察复方甘草酸苷联合川芎嗪治疗酒精性肝病的疗效。方法:将160例酒精性肝病患者随机分为对照组、复方甘草酸苷组、川芎嗪组及联合治疗组,治疗4周后观察肝功能、肝纤维化指标、转化生长因子β1(TGFβ1)、白细胞介素-6(IL-6)、瘦素(Leptin)及肿瘤坏死因子-α(TNF-α)。结果:各组治疗后肝功能较治疗前均显著好转,肝纤维化指标、TGFβ1、IL-6、Leptin及TNF-α较治疗前均显著下降(P<0.05),对照组、复方甘草酸苷组及川芎嗪组之间治疗后肝功能、肝纤维化指标、TGFβ1、IL-6、Leptin及TNF-α无显著性差异(P>0.05),联合治疗组治疗后肝功能较对照组、复方甘草酸苷组及川芎嗪组显著改善(P<0.05),肝纤维化指标、TGFβ1、IL-6、Leptin及TNF-α较对照组、复方甘草酸苷组及川芎嗪组显著下降(P<0.05)。结论:复方甘草酸苷联合川芎嗪治疗酒精性肝病有效。Objective：To observe the curative effects of compound glycyrrhizin combined with ligustrazine on patients with alcoholic liver disease. Mcthods：160 cases of alcoholic liver disease were randomly divided into four groups：control group, compound glycyrrhizin group,ligustrazine group and combined treatment group. The parameters of hepatic function and fibrosis were observed four weeks after treatment. Results：The parameters of hepatic function were improved after treatment and fibrosis,TGFβ1, IL-6,Leptin, TNF-α after treatment in four groups were lower than those before treatment （P 〈 0.05）. The parameters of hepatic function,fibrosis, TGFβ1 ,IL-6,Leptin and TNF-α after treatment among control group,compound glycyrrhizin group and ligustrazine group had no significance （P 〉 0.05）. Compared with control group, compound glycyrrhizin group and ligustrazine group,the parameters of hepatic function, fibrosis, TGFβ1, IL-6, Leptin,TNF-α of combined treatment group after treatment were obviously improved （P 〈 0.05）. Conclusion： Compound glycyrrhizin combined with ligustrazine are effective for the treatment of alcoholic liver disease.

关 键 词：复方甘草酸苷 川芎嗪 酒精性肝病 疗效 

分 类 号：R575.2[医药卫生—消化系统]