PTEN抑癌基因异常与肿瘤靶向治疗  

Abnormalities of PTEN tumor suppressor gene and tumor targeted therapy

作　　者：姚书娜(综述)[1] 刘艳艳(审校)[1] 杨树军(审校)[1] 

机构地区：[1]郑州大学第一附属医院肿瘤内科,450001

出　　处：《国际肿瘤学杂志》2009年第10期763-765,共3页Journal of International Oncology

摘　　要：PTEN在肿瘤中存在基因组、基因转录、翻译和翻译后等多个水平的异常，从而导致P13K／Akt通路的过度激活。这不仅是肿瘤发生的重要机制，也与某些靶向治疗后的耐药相关。克服PTEN异常所致耐药的方法包括直接应用作用于P13K／Akt通路的新型靶向药物以及重新恢复PTEN基因的表达和功能。PTEN is a powerful tumor suppressor gene located at chromosome 10q23, which exists multi-level abnormalities in cancer, including genome, gene transcription, protein translation and post-translation, which can result in overactivation of PI3K/Akt pathway. They are not only related to tumorigenesis, but also associated with resistance to targeted drugs in cancer. When it comes to overcome the resistance, novel PI3K/ Akt pathway inhibitors and approaches to restore the expression and function of PTEN may be considered.

关 键 词：基因 肿瘤抑制 药物疗法 PTEN磷酸水解酶 

分 类 号：R737.33[医药卫生—肿瘤] R730.5[医药卫生—临床医学]