利用心率的去趋势波动分析提取睡眠呼吸暂停低通气综合症患者的睡眠结构信息  

Detrended Fluctuation Analysis of Heart Rate to Detect Sleep Stage for Patients with Sleep Apnea Hypopnea Syndrome

作　　者：郑慧君[1] 王海涛[1] 曹征涛[2] 朱莹莹[1] 姬超[3] 俞梦孙[2] 

机构地区：[1]山东大学控制科学与工程学院,济南250061 [2]空军航空医学研究所,北京100142 [3]空军总医院,北京100142

出　　处：《中国生物医学工程学报》2009年第5期647-651,共5页Chinese Journal of Biomedical Engineering

基　　金：国家科技支撑计划(2006BAI03A00)

摘　　要：以经基于心率变异性的睡眠分期大都是针对健康人进行的,拟利用心率变异性分析睡眠呼吸暂停低通气综合症(SAHS)病人的睡眠结构。根据微动敏感式床垫式睡眠监测系统(MSMSMS)所得10名健康者的心率和30名不同程度SAHS患者的心率,利用去趋势波动分析(DFA)方法,计算他们在各睡眠阶段的标度指数。实验结果显示,SAHS患者各个睡眠阶段的标度指数具有明显差异,与健康者也有不同,为基于心率变异性对SAHS患者进行睡眠分期以及SAHS患者的判定提供了依据。This study is purposed to distinguish sleep stage based on heart rate variability for sleep apnea hypopnea syndrome （SAHS） patients. The heart rate of 10 healthy subjects and 30 SAHS petients, detected from the micro- movement sensitive mattress sleep monitoring system （MSMSMS）, was analyzed using detrended fluctuation analysis （DFA）, and fractal exponents in different sleep stage were calculated. The results showed that the fractal exponents had significant differences in different sleep stage for the SAHS patients, and they were also different between healthy subjects and SAHS patients. All of these gave the potential for the application of heart rate variability in distinguishing sleep stage of SAHS patients and diagnosing SAHS as well.

关 键 词：心率 睡眠呼吸暂停低通气综合症 睡眠分期 去趋势波动分析 标度指数 

分 类 号：R318[医药卫生—生物医学工程]