基于弹性小球动态平衡的血管中心线和直径的测量  

Measurement of Vascular Centerline and Diameter Using Dynamic Balance of Bouncing Balls

作　　者：陆荣生[1] 易红[1] 倪中华[1] 齐建昌[1] 

机构地区：[1]东南大学江苏省微纳生物医疗器械设计与制造重点实验室,南京211189

出　　处：《中国生物医学工程学报》2009年第5期668-673,685,共7页Chinese Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(50805022;60873152);江苏省自然科学基金资助项目(BK2008280)

摘　　要：血管中心线及直径的测量是血管类疾病诊断和微创介入治疗的重要依据。当前研究主要依据图像细化算法,但是细化算法缺乏计算结果的一致性。提出一种基于弹性小球动态平衡的血管中心线和直径的测量方法。首先在血管内部以交互的方式输入一条多段线(polyline)来确定感兴趣的血管部位,然后对多段线离散化为一组点,通过对离散点逐步膨胀为小球以及在小球与血管壁碰撞的两个力影响下,对小球和多段线同时变形,最后在平衡状态下得到的多段线即是血管中心线,小球直径就是该处血管直径。实验中,通过对模拟血管图像和临床DSA图像的量化测量及与常用方法对比,表明所提出算法能够精确地得到血管中心线与血管直径。Measurement of vascular centerline and diameter is a fundamental step in diagnosing vascular diseases and planning minimally invasive surgery. Current research is mainly based on image thinning techniques, but different thinning algorithms can not guarantee the consistency of different algorithms. This paper presented an original approach using the dynamic balance of bouncing balls to measure the vascular centerline and diameter in angiogram. A polyline was first inputted inside the vascular disease region, and automatically descretized to a set of points attached with initial balls. Then, the center and radius of each ball were deformed under the elastic expending force and the bouncing force from vascular boundary. When every ball reached a stable state, the deformed polyline and ball diameters represented the vascular centerline and local diameters, respectively. The proposed method was tested using simulated vascular images and raw DSA images and compared with other approaches. The results showed that the method of dynamic balance of bouncing balls was robust and effective in extracting vascular centerline and diameters for medial treatments.

关 键 词：血管中心线 血管直径 细化算法 图像分割 

分 类 号：R318[医药卫生—生物医学工程]