聚乳酸根管桩浸提液对人牙囊细胞生物学性能的影响  

Effects of PLA post leaching liquor on biological characteristics of human dental follicle cells

作　　者：邹艳萍[1] 李石保[1] 冀堃[1] 王茜[1] 杨富生[1] 轩昆[1] 

机构地区：[1]第四军医大学口腔医学院,陕西西安710032

出　　处：《牙体牙髓牙周病学杂志》2009年第10期567-570,共4页Chinese Journal of Conservative Dentistry

基　　金：自然科学基金青年基金(30600709);陕西省自然科学基金-社发公关项目[2006k11-G1(2)];第四军医大学口腔医学院临床高新项目

摘　　要：目的:观察聚乳酸根管桩浸提液对人牙囊细胞生物学功能的影响。方法:取第4代人牙囊细胞,分别用50%、100%聚乳酸根管桩浸提液作用1、3、5、7d,观察其对细胞增殖和凋亡的影响。结果:两种浓度聚乳酸根管桩浸提液组在各时间点的A值与正常培养液组相比均无显著差异(P>0.05),细胞毒性等级均为1级。活细胞百分率空白对照组为94.2%;100%浸提液组为84.5%,两组差异不明显,无统计学意义(P>0.05)。结论:可吸收性聚乳酸根管桩无明显细胞毒性,不会引起细胞凋亡。AIM：To observe the effects of the leaching liquor from PLA post on biological characteristics of human dental follicle cells （HDFCs）. METHODS： The fourth passage of cultured HDFCs were immersed in leaching liquor of PLA post with 50% and 100% seperately for 1,3,5,7 days. Changes and proliferation of the ceils were observed. RESULTS：There were no significant differences in cell apoptosis and cell toxicity between the experiment group and the control group （ P 〉 0.05 ）. The cell toxicity were classified as I grade. The percentage of the vital ceils of control group and 100% leaching liquor groups were 94.2% and 84.5% respectively. The difference is not obvious and no statistical importance （P 〉 0.05）. CONCLUSION：The absorbable PLA post doesn＇t have cell toxicity and can＇t cause cell apoptosis.

关 键 词：聚乳酸 根管桩 人牙囊细胞 生物学性能 

分 类 号：R780.2[医药卫生—口腔医学]