WHBE兔血气-电解质分析及与日本大耳白兔和新西兰白兔比较研究  

Analysis on Blood Gas and Electrolytes of WHBE Rabbits and Compared with Japanese White Rabbits and New Zealand White Rabbits

作　　者：陈民利[1] 吕建敏[1] 徐孝平[1] 潘永明[1] 徐剑钦[1] 王德军[1] 

机构地区：[1]浙江中医药大学动物实验研究中心／比较医学研究中心,杭州310053

出　　处：《实验动物与比较医学》2009年第5期331-333,346,共4页Laboratory Animal and Comparative Medicine

基　　金：浙江省公共科技基础平台项目（Dwpt-bz-12）;受“浙江省卫生高层次创新人才培养工程项目”资助

摘　　要：目的探讨WHBE兔、日本大耳白兔和新西兰白兔血气、电解质指标的差异性。方法取WHBE兔、日本大耳白兔和新西兰白兔经耳中动脉取肝素抗凝血，在NOVA血气电解质分析仪上测定血气、电解质指标。结果与日本大耳白兔比较，WHBE兔pH值、PCO2、PO2、SO2、BE-ECF、BE-B、SBC、HCO3^-、TCO2、a／A和P02／FI11个指标均明显低于日本大耳白兔（P〈0．05，P〈0．01），而Osm、Na^＋和Mg^＋＋明显高于日本大耳白兔（P〈0．01）；与新西兰白兔比较，WHBE兔pH值明显低于新西兰白兔（P〈0．01）。而Mg^＋＋明显高于新西兰白兔（P〈0．01）。结论上述结果为WHBE兔标准化提供可靠的生物学数据，同时为WHBE兔在呼吸系统和心血管疾病中的应用提供了实验依据。Objective To investigate the difference of blood gas and electrolytes among WHBE rabbits, Japanese white rabbits, New Zealand white rabbits. Methods WHBE rabbits, Japanese White rabbits and New Zealand White rabbits were selected and the blood sample were taken from center artery in ear, the blood gas and electrolytes indexes were detected by NOVA blood gas and electrolytes analyzers. Results Compared with Japanese White rabbits, pH, PCO2, PO2, SO2, BE-ECF, BE-B, SBC, HCO3, TCO2, a/A and POdFI indexes were significantly lower in WHBE rabbits than those of Japanese White rabbits（P〈0.05, P〈0.01）, while Osm, Na^＋ and Mg^＋＋ indexes were higher in WHBE rabbits than those of Japanese white rabbits（P〈0.01）. Compared with New Zealand White rabbits, pH index was significantly lower in WHBE rabbits than that of New Zealand White rabbits（P〈0.01）, while Mg^＋＋ index was higher in WHBE rabbits than that of New Zealand White rabbits（P〈0.01）. Conclusion The results above could provide a reliable data for the standardization of WHBE rabbits in China, meanwhile, it could provide an experimental basis for the research application of WHBE in respiration system and cardiovascular disease.

关 键 词：WHBE兔 血气 电解质 日本大耳白兔 新西兰白兔 

分 类 号：R-332[医药卫生] R363