脓毒症中的细胞凋亡  

Apoptosis in sepsis

作　　者：张彦[1] 姜叙诚[1] 郭晓奎[2] 

机构地区：[1]上海交通大学医学院病理学教研室,上海200025 [2]上海交通大学医学院病原生物学教研室,上海200025

出　　处：《中国病理生理杂志》2009年第10期2068-2072,共5页Chinese Journal of Pathophysiology

基　　金：国家863计划资助项目(No.2006AA02Z176);国家自然科学基金资助项目(No.30370071;No.30670102)

摘　　要：Immune cells that undergo increased apoptosis include lymphocytes and macrophages,yet the apoptosis of neutrophils is decreased in sepsis.Increase in apoptosis has also been reported in non-immune cells such as gastrointestinal cells,epithelial cells of lung as well as endothelial cells.The altered apoptotic cell death may contribute to the initiation and aggravation of immune and organ dysfunction in sepsis.Elucidating the changes and mechanism of apoptosis and taking measures to control apoptosis may be an effective strategy for the treatment of sepsis.Immune cells that undergo increased apoptosis include lymphocytes and macrophages, yet the apoptosis of neutrophils is decreased in sepsis. Increase in apoptosis has also been reported in non - immune cells such as gastrointestinal cells, epithelial cells of lung as well as endothelial cells. The altered apoptotic cell death may contribute to the initiation and aggravation of immune and organ dysfunction in sepsis. Elucidating the changes and mechanism of apoptosis and taking measures to control apoptosis may be an effective strategy for the treatment of sepsis.

关 键 词：脓毒症 细胞凋亡 细胞因子类 

分 类 号：R363.21[医药卫生—病理学]