肥胖基因的研究进展  

Research Progress on the Obese Gene

作　　者：周炜[1,2] 缪为民[1,2] 焦炳华 

机构地区：[1]复旦大学遗传学研究所 [2]第二军医大学微生物学教研室

出　　处：《生物化学与生物物理进展》1998年第4期299-303,共5页Progress In Biochemistry and Biophysics

摘　　要：肥胖症是摄食和能耗平衡机制的失调，可引起多种疾病，如Ⅱ型糖尿病、高血压、高血脂和癌症等．肥胖基因的克隆为研究肥胖的机制提供了重要途径．肥胖基因编码消瘦激素，作用于下丘脑，控制代谢、能耗和生殖系统．实验表明，重组的消瘦激素具有使肥胖基因缺陷和神经肽Ｙ缺陷小鼠代谢和体重正常化，恢复肥胖基因缺陷小鼠生育能力等活性．进一步研究肥胖基因作用机制，开发针对各种缺陷的药物，能使肥胖症的治疗成为可能．Obesity is the disorder of the mechanisms in balancing food intake and energy expenditure. It leads to several diseases such as type Ⅱ diabetes,hypertension,hyperlipidaemia and cancers. The positional cloning of the obese gene provides an important approach to the research of the mechanisms of obesity. Leptin,the product of obese gene,acts on the hypothalamus, controlling metabolism, energy expenditure and reproductive system. Research data showed that the recombinant leptin normalized the metabolism and body weight of the obese gene defficiency mice and the neuropeptide Y defficiency mice,corrected the sterility of the obese gene defficiency mice. Further researches on the mechanisms of the obese gene and development of the drugs according to different kinds of defficiency can make it possible to the treatment of obesity.

关 键 词：肥胖基因 定位克隆 消瘦激素 消瘦激素受体 

分 类 号：Q75[生物学—分子生物学]