药物代谢酶及转运体与前列腺癌药物治疗  

Drug-Metabolizing Enzymes and Transporters: Roles in the Human Prostate Cancer Chemotherapy

作　　者：赵超群[1] 张天禹[1] 尤剑鹏[1] 谭宁[2] 

机构地区：[1]桂林医学院附属医院,广西桂林541001 [2]桂林医学院生物技术学院,广西桂林541001

出　　处：《现代生物医学进展》2009年第18期3578-3581,共4页Progress in Modern Biomedicine

基　　金：广西壮族自治区卫生厅医疗卫生重点科研课题(项目编号:200982);科技部癌基因及相关基因国家重点实验室开放课题(项目编号:90-08-01);广西壮族自治区卫生厅科研课题(项目编号:Z2007320)

摘　　要：药物代谢酶是催化体内摄入的各种药物进行生物转化的一系列重要酶,属于生物转化酶系中的一类。虽然药物生物转化的主要场所在肝脏,但在肝外组织(如前列腺)亦存在,而且可影响药物在局部的生物转化率。药物转运体在药物的跨膜转运中发挥了重要的作用,影响了药物在体内的药代动力学进程,药物转运体在组织中分布广泛;本文着重阐述这些药物代谢酶及转运体在治疗前列腺癌药物中的作用,及它们在前列腺中的特异性表达,同时讨论了在不同的治疗策略中与药物代谢酶及转运体相关的靶向作用。Drug-metabolizing enzymes are those that catalyze a reaction in the physical form of ingested all sorts of drugs, It belongs to a part of biotransformation enzymes. Although the principal site of drug biotransformation is the liver, but it is now clear that drug-metabolizing enzymes are present in extrahepatic tissues, including the prostate and may affect local rates of drug biotransformation. Transporters show important role in the transport of the drug crossing cellularmembrane. And they effect pharmacokinetic process of drug in the body. Drug transporters are widely distributed in tissues and overexpression of these genes is associated with drug resistance. This paper focuses on the role of biotransformation enzymes and transporters used in the management of prostate cancer. Targeting of drug-metabolizing enzymes and transporters in different therapeutic strategies is also discussed.

关 键 词：药物代谢酶 药物转运体 前列腺癌 

分 类 号：R737.25[医药卫生—肿瘤]