庆大霉素研究概述  

Research Progress on Gentamicin

作　　者：郭家瑞[1] 王卫国[1] 李磊[1] 何泓良[1] 

机构地区：[1]河南工业大学生物工程学院,郑州450001

出　　处：《海峡药学》2009年第10期5-8,共4页Strait Pharmaceutical Journal

基　　金：河南工业大学引进人才专项(2007BS023)

摘　　要：庆大霉素是由绛红色小单胞菌、棘孢小单胞菌产生的一种氨基糖苷类抗生素。由于其抗菌谱广、抗菌作用强,尤其对革兰氏阴性菌引起的感染治疗效果较好,因此被广泛应用于临床。本文综述了近年来国内外关于庆大霉素发酵工艺、提纯方法的研究现状,并结合当前实际分析了庆大霉素的应用与发展前景。Gentamicin,an aminoglycoside antibiotic,is generated by Micro-monospora purpurea and Aeromonas small spikes.It has been widely used clinically because of its antimicrobial broad-spectrum and antibacterial activity,especially for its higher therapeutic effect on gram-negative bacteria.This paper outlined the research situation on the gentamicin fermentation process and its isolation and purification methods both at home and abroad in recent years.At the same time,the applications and prospects of gentamicin were diseussed with the present actual situation.

关 键 词：庆大霉素 发酵工艺 提纯 临床应用 发展前景 

分 类 号：R978.1[医药卫生—药品]