缺血性脑血管病患者血清超敏C-反应蛋白水平及与MR弥散成像对比分析  

Serum Level of High Sensitive C-Reactive Protein in Ischemic Cerebrovascular Disease and Its Relation to the Results of MR Diffusion-Weighted Imaging

作　　者：姜振威[1] 周珂[1] 于弋水[1] 

机构地区：[1]武汉大学人民医院神经内科,湖北武汉430060

出　　处：《武汉大学学报（医学版）》2009年第5期663-666,共4页Medical Journal of Wuhan University

摘　　要：目的:探讨缺血性脑血管病患者血清超敏C-反应蛋白(hs-CRP)水平,与MR弥散成像(DWI)及缺血损伤的严重程度的关系,从而判断血清hs-CRP水平在急性缺血性脑血管病早期诊断及预后评估中的意义。方法:收集2008年1-7月在我院神经内科住院的缺血性脑血管病患者182例,记录其影像学(DWI)资料、入院后2 h内血清hs-CRP水平。分成3组,即急性脑梗塞组、非急性期脑梗塞组及短暂性脑缺血发作组,并选择健康体检者33例作为对照组,急性脑梗塞组按照DWI上显示的病变部位及面积分为3个亚组(A组:TIA组;B组:小面积梗塞组,C组:大面积梗塞组)。比较各组间血清hs-CRP水平,并与DWI进行相关分析。结果:血清hs-CRP水平在急性脑梗塞组最高,TIA组次之,差异具有统计学意义(P<0.01);非急性期脑梗塞组与正常对照组间差异无显著性(P>0.05)。Spearman’s相关分析显示hs-CRP水平与DWI显示的梗死部位及面积有显著相关性(P<0.01)。结论:hs-CRP水平在急性缺血性脑血管病患者中升高,与缺血的范围及严重程度密切相关;与DWI显示的梗死面积及部位具有相关性,两者结合可共同用于脑缺血的早期诊断和病情严重程度的评估。Objective： To determine the diagnostic value of the serum high sensitive C-reactive protein（hs-CRP） level in ischemic cerebrovascular disease and to compare the level of hs-CRP with the diffusion-weighted imaging（DWI） results in acute stroke.Methods： One hundred and eighty-two patients with ischemic cerebrovascular disease were divided into three groups： acute cerebral infarction,transient ischemic attack（TIA）,and non-acute cerebral infarction groups,and another thirty-three healthy subjects were involved in this study as control group.The level of serum hs-CRP in different groups was determined and compared and the correlation to DWI results was analyzed.Results： The serum hs-CRP in acute cerebral infarction group were significantly higher than in other groups（P〈0.01）.The serum hs-CRP in TIA group were significantly higher than that in non-acute cerebral infarction group and control group respectively（both P〈0.05）,and there was no significant difference between non-acute cerebra...更多l infarction group and control group.Spearman rank correlation test demonstrated that there was a significant correlation between the serum hs-CRP level and the results of DWI（P〈0.01）.Conclusion： The serum hs-CRP level of acute cerebral infarction and TIA group was increased,and was associated with the degree and extent of ischemic damage showed in DWI.Both serum hs-CRP assay and DWI could be used for early diagnosis and clinical assessment of ischemic cerebrovascular disease.

关 键 词：超敏C-反应蛋白 DWI 急性缺血性卒中 短暂性脑缺血发作 

分 类 号：R743[医药卫生—神经病学与精神病学]