珠海市部分人群肺癌危险因素病例对照分析  

Case-control study of risk factors of lung cancer in Zhuhai

作　　者：梁小冬[1] 李德云[1] 吴少芳[1] 谭爱军[1] 陈琦[1] 陈国荣[1] 陈惠娟[1] 吴兆伦[2] 周伴群[2] 

机构地区：[1]珠海市疾病预防控制中心,广东珠海519002 [2]珠海市疾病预防控制中心西部中心

出　　处：《华南预防医学》2009年第5期31-34,共4页South China Journal of Preventive Medicine

基　　金：2007年珠海市科学技术局科技计划项目(编号:PC20071048)

摘　　要：目的探讨珠海市人群肺癌的相关危险因素。方法采用1∶1配对的病例对照研究方法,选取肺癌死亡个案及对照各131例,调查其一般情况、生活居住环境、工作环境、饮食习惯、生活方式、健康和精神状况等与肺癌有关的7个方面,对疾病史、肿瘤家族史、吸烟、被动吸烟、饮酒、煤炉使用年限、房屋通风、职业史、居住地点和工作时间等45个因素采用条件logistic回归方法进行单因素和多因素分析,筛选主要危险因素。结果多因素logistic回归分析显示,吸烟(OR=2.309)、肿瘤家族史(OR=3.348)、厨房油烟大(OR=3.726)、房子通风差(OR=7.989)与肺癌死亡有关(P<0.05)。剂量-反应分析显示吸烟与肺癌发病呈剂量反应关系(P<0.05),吸烟少于10支、10～19支、20～40支组的OR值分别为3.250、2.158、3.431。结论吸烟、肿瘤家族史、厨房油烟大、房子通风差可能是珠海市部分人群肺癌主要危险因素。加强控烟和改善居住环境是预防肺癌的重要措施。Objective To explore the risk factors associated with lung cancer in Zhuhai population. Methods A 1 ： 1 matched design of case - control study was performed. A total of 131 lung cancer patients and 131 matched controls were randomly selected from the residents of Zhuhai City. A standard questionnaire was used to collect information related to lung cancer including general status, living condition, work condition, life style, dietetic habit, health and inspirit status. Forty - five primary risk factors including disease history, family cancer history, smoke, alcohol, coal stove using, ventilation, occupation history, living condition and work time were studied and screened with single factor and multi - factor conditional logistic regression analysis. Results The results of multi - factor logistic regression analysis showed that smoking（ OR = 2. 309 ）, family history of tumor （ OR = 3. 348 ） , cooking oil fume （ OR = 3. 726） and poor ventilation （ OR = 7. 989 ） were significantly related to lung cancer （ P 〈 0.05 ）. The results of single factor logistic regression analysis showed that correlativity between smoking and lung cancer presented a doseeffect relationship, in which the OR values of less than 10 cigarettes, 10 -19 cigarettes and 20 -40 cigarettes per day were 3. 250, 2. 158 and 3. 431, respectively. Conclusion The risk factors influencing the incidence of lung cancer in Zhuhai population were smoking, family history of tumor, cooking oil fume and bad ventilation. It is the important measurement for lung caner prevention to strengthen smoking control and improve inhabitancy environment.

关 键 词：肺肿瘤 病例对照研究 因素分析 统计学 

分 类 号：R734.2[医药卫生—肿瘤]