人脑对视觉信息变化的处理过程的事件相关电位研究  

Dynamic Process of Visual Change Detection in Human Brain:an ERP Study

作　　者：毛薇[1] 韩春玉[1] 孙伟[1] 王红星[2] 甄文凤[2] 王玉平[1] 

机构地区：[1]首都医科大学宣武医院,北京100053 [2]首都医科大学附属北京安定医院,北京100088

出　　处：《中国心理卫生杂志》2009年第11期832-838,共7页Chinese Mental Health Journal

基　　金：国家自然科学基金(30800366)

摘　　要：目的:采用256导联事件相关电位技术和低分辨率电磁图的方法,研究人脑对视觉信息变化的处理过程。方法:12名健康志愿者参与试验。视觉刺激为同时具有颜色和形状2种特征的图形。先后呈现的2张图片(S1和S2)组成一个刺激对并分为4种类型:S1和S2的颜色、形状均相同;S1和S2的颜色相同,形状不同;S1和S2的颜色不同,形状相同;S1和S2的颜色、形状均不同。受试者分别完成注意颜色和注意形状2个任务。结果:①S2呈现后135ms～165ms,3种变化的刺激对引出了变化相关正波(change-related positivity,CRP)。低分辨率电磁图(low-resolution electromagnetic tomography,LORETA)分析显示CRP的发生源是枕叶舌回、楔叶。②235ms～275ms时间窗内,无变化和无关变化状态引出了N200,右侧颞叶梭状回、颞中回和海马旁回是该成分的发生源。③240ms～320ms时间窗内,所有变化的刺激对均引出了N270,前扣带回和双侧杏仁核是N270的发生源。结论:人脑对视觉信息变化的处理过程可分为3个阶段:CRP所代表的可能是人脑对视觉信息变化的早期处理阶段;N200所反映的可能是人脑对无关信息变化的主动忽略阶段;N270可能代表高级处理阶段。Objective： To explore the spatio-temporal dynamics of brain mechanisms in visual change detection by 256-channel event-related potential （ERP） and low-resolution electromagnetic tomography （LORETA） analyses. Methods： ERP were recorded in 12 healthy participants during performing an S1-S2 matching task. Visual stimuli defined by color and shape. Each trial consisted of two sequentially presented stimuli （ S1 and S2 ） , where S2 was either the same as S1, different from S1 in shape only, different in color only, or different in both color and shape. Subjects matched the stimuli according to task demands： attending to color and attending to shape. Result： Change condition elicited change-related positivity （ CRP） ranging 135 - 165 ms. The estimated source regions contributing to CRP were lingual gyrus and cuneus of occipital lobe. N200 was elicited in no change and task-irrelevant change condition ranging 235 -275 ms. The source for N200 was in the right temporal fusiform gyrus, middle temporal gyrus and parahippocampai gyrus. In the time window of 240 -320 ms, N270 was elicited in all change conditions. The N270 source was localizable to the anterior cingulated cortex and amygdala. Conclusion： In the early stage, CRP reflects the preattentive processing of visual changes. The LORETA result confirms that CRP is genera- ted in the early visual areas. N200 may be related to the active ignored processing of task-irrelevant change. The source for N200 is in the right temporal fusiform gyrus, middle temporal gyrus and parahippocampal gyrus. In thelate stage, N270 reflects the advanced processing of visual change in the human brain. The N270 source may be in anterior cingulate cortex （ACC ） and amygdala.

关 键 词：视觉信息变化 事件相关电位 低分辨率电磁图 变化相关正波 N200 N270 

分 类 号：R741.044[医药卫生—神经病学与精神病学] B842[医药卫生—临床医学]