脑缺血耐受现象的临床研究  

The clinical investigation of ischemic tolerance of brain

作　　者：王琰萍[1] 张晓玲[1] 黄俊军[1] 朱敏初[1] 许丽珍[2] 

机构地区：[1]嘉兴医学院附属第二医院神经内科,314000 [2]苏州大学附属第一医院神经内科

出　　处：《中国医师进修杂志（内科版）》2009年第11期3-5,共3页Chinese Journal of Postgraduates of Medicine

基　　金：基金项目：浙江省嘉兴市科技局计划（2006AZ2008）

摘　　要：目的 探讨继发于短暂性脑缺血发作（TIA）的脑梗死是否存在缺血耐受现象。方法136例首次急性脑梗死患者分为有同侧TIA史的38例患者（有TIA组）及无同侧TIA史的98例患者（无TIA组），测定两组患者入院时血小板活化因子（CD62P）阳性表达率，头颅MRI测量梗死面积，并评定其入院时及发病第30天的日常生活能力（ADL）评分。结果有TIA组患者入院时CD62P阳性表达率低于无TIA组[（4．21±0．43）％比（6．01±0．03）％，P〈0．05]：有TLA组患者梗死面积较无TIA组小（P〈0．05）。有TIA组患者发病第30天时ADL评分低于无TIA组[（21．12±1．45）分比（30．83±3．47）分，P〈0．05]结论继发于TIA的脑梗死存在缺血耐受现象。Objective To explore whether isehemic tolerance exists in patients of cerebral infarction following transient isehemic attacks （TIA）. Methods Thirty-eight patients with cerebral infarction following TIA（with TIA group） and 98 patients with cerebral infarction without TIA （without TIA group）were studied. The positive expression rate of CD62P in platelet and the size of cerebral infarction on admission was measured. The scores of activities of daily living were evaluated on admission and after a month. Results The positive expression rate of CD62P in platelet was lower in with TIA group than that in without TIA group [ （4.21 ±0.43 ）% vs （6.01 ± 0.03 ）%, P 〈 0.05 ]. The area of cerebral infarction and the scores of activities of daily hving were lower in with TIA group than those in without TIA group（P 〈 0.05）. Conclusion Cerebral infarction following TIA has isehemie tolerance.

关 键 词：脑梗塞 血小板活化因子 脑缺血 

分 类 号：R743.31[医药卫生—神经病学与精神病学] R743.33[医药卫生—临床医学]