300例肺癌患者淋巴细胞计数结果分析  

Analysis of Lymphocyte Count in 300 Lung Cancer Patients

作　　者：周文[1] 张鹏[1] 宋世辉[1] 温昱鹏[1] 吕扬[1] 张健[1] 

机构地区：[1]天津医科大学总医院心胸外科,天津300052

出　　处：《中国肺癌杂志》2009年第10期1127-1129,共3页Chinese Journal of Lung Cancer

摘　　要：背景与目的淋巴细胞具有产生和运载抗体等维持机体免疫功能的作用,已有研究显示肿瘤与血液中淋巴细胞计数存在一定的相关性。本研究分析肺癌患者淋巴细胞表达水平并探讨其临床意义。方法将300例肺癌初治患者设为实验组,同期住院50例肺良性病者作为对照组,所有患者均于入院后第一天晨起采血后2h内用Sysmex XE-2100全自动血细胞分析仪计数。将实验组及对照组淋巴细胞百分率和淋巴细胞绝对值与正常人群参考值比较分析。结果肺癌患者淋巴细胞百分率和淋巴细胞绝对值与正常人群参考值相比差异有统计学意义,而肺良性病者与正常人相比无统计学差异。肺恶性病较良性病淋巴细胞百分率和绝对值低表达发生率高(32.0%/8.0%和18.3%/6.0%),差异有统计学意义(P<0.005)。结论血象中淋巴细胞百分率和淋巴细胞绝对值分析能够对肺癌等恶性肿瘤的发病机理起一定的指导意义。Background and objective Lymphocytes could produce antibody and then delivery it, which are the maintenance of immune function. It has been proven that lymphocyte count in the blood had correlation with the tumor. The aim of this study was to analyze the expression level of lymphocytes in patients with lung cancer and to discuss its clinical signifi- cance. Methods 300 cases of newly diagnosed patients with lung cancer were used as the experimental group, and 50 cases with lung benign lesion were the control group. The level of lymphocyte count was detected by Sysmex XE-2100, the percentage and absolute value of lymphocyte was compared with normal population reference between the experimental group and the control group. Results Compared to the normal crowd, the percentage and the absolute value of lymphocyte in patients with lung cancer had significant difference but benign lung disease; malignant lung disease had higher incidence of low lymphocyte count than the benign disease （32.0%/8.0% and 18.3%/6.0%）, P〈0.005, existing significant statistic difference. Conclusion The analysis of lymphocyte count in peripheral blood has certain guiding significance in pathogenetic of many malignant tumors.

关 键 词：淋巴细胞 肺肿瘤 肺良性病 免疫功能 

分 类 号：R734.2[医药卫生—肿瘤]