非小细胞肺癌淋巴结转移CT表现与血管内皮生长因子-C及淋巴管生成的相关性研究  

The correlation between the lymph node involvement signs on computed tomography and VEGF-C as well as the lymphatic vessel density in non-small cell lung carcinoma

作　　者：严金岗[1] 张铁英[1] 李春生[2] 王和平[1] 周海伟[1] 曹捍波[1] 张善华[1] 

机构地区：[1]浙江省舟山市人民医院放射科,浙江舟山316004 [2]浙江省舟山市人民医院病理科,浙江舟山316004

出　　处：《医学影像学杂志》2009年第10期1258-1261,共4页Journal of Medical Imaging

摘　　要：目的:探讨非小细胞肺癌(NSCLC)淋巴结转移CT表现与肿瘤血管内皮生长因子C(VEGF-C)、肿瘤淋巴管密度(lymphatic vessel density,LVD)间的相关性。方法:搜集60例经手术病理证实的NSCLC,术前均行CT平扫及增强扫描,对手术病理标本应用免疫组织化学染色法(P-V法)检测肿瘤组织VEGF-C及LVD,分析淋巴结转移CT表现与VEGF-C、LVD间的相关性。结果:60例NSCLC中,淋巴结转移的CT表现阳性组VEGF-C、LVD均高于阴性组。结论:螺旋CT增强扫描所示淋巴结转移CT表现与VEGF-C及LVD相关,可间接反映其含量。Objective：To investigate the correlation between the expression of vascular endothelial growth factor C（VEGF-C） and lymphatic vessel density（LVD） as well as the lymph node involvement with CT signs in human non-small cell lung cancer（NSCLC）.Methods：Sixty patients with NSCLC were examined with plain and enhanced SCT scanning and proved surgically and pathologically.The resected tumor specimens were immunohistochemically stained（P-V method）for measuring VEGF-C and LVD.The results were compared with the lymph node involvement with CT signs.Results：In 60 NSCLC,VEGF-C and LVD in the lymph node involvement features observed on CT group was significantly higher than that in the negative group.Conclusion：The lymph node involvement features observed on CT scan are closely correlated with VEGF-C and LVD in NSCLC,which can reflect the expression of the markers.

关 键 词：肺肿瘤 淋巴管密度 体层摄影术 X线计算机 

分 类 号：R734.2[医药卫生—肿瘤] R814.42[医药卫生—临床医学]