COX-2在骨巨细胞瘤及骨肉瘤中的表达及其临床意义  

The expression and clinical significance of cox-2 in osteosarcoma and giant cell tumor of bone

作　　者：黄建军[1] 石莺[1] 向志刚[1] 田志良[1] 罗家顺[1] 

机构地区：[1]吉首大学医学院外科学教研室,湖南吉首416000

出　　处：《中国医师杂志》2009年第10期1345-1347,共3页Journal of Chinese Physician

基　　金：基金项目：湖南省教育厅科研课题资助项目（07C514）

摘　　要：目的检测54例骨巨细胞瘤及37例骨肉瘤组织中COX-2的表达，分析其对骨巨细胞瘤及骨肉瘤的临床诊断及预后的意义。方法应用免疫组化方法对54例骨巨细胞瘤及37例骨肉瘤组织中COX-2进行检测。结果54例骨巨细胞瘤组织中有29例COX-2表达阳性，其表达与骨巨细胞瘤分期无关（P〉0．05），与复发有关（x^2=10．85，C=0．80，P〈0．01）。37例骨肉瘤组织中有32例COX-2表达阳性，其表达与骨肉瘤分期有关（x^2=4．16，C=0．56，P〈0．05），与肿瘤组织学类型无关。结论COX-2与骨巨细胞瘤的复发及骨肉瘤的分期有关，其可为骨巨细胞瘤和骨肉瘤的临床诊断和预后判断提供帮助。Objective To investigate the expression of cox-2 in 37 cases of osteosarcoma and 54 cases of giant cell tumor of bone, and analyze its significance in diagnosis and prognosis of osteosarcoma and giant cell tumor of bone. Methods Immunohistochemical strain was used to detect the expression of cox-2 in 37 cases of osteosarcoma and 54 cases of giant cell tumor of bone. Results 29 cases of giant cell tumor of bone were cox-2 positive, the expression of cox-2 was related to the recurrence. 32 cases of osteosarcoma were cox-2 positive. The expression of cox-2 was related to the grade, but not related to the differentiation. Conclusion Cox-2 was related to the generation and prognosis, it may be an indicator for clinical diagnosis and prognosis evaluation of osteosarcoma and giant cell tumor of bone.

关 键 词：前列腺素内过氧化物合酶/代谢 骨肉瘤/代谢 巨细胞瘤 骨/代谢 

分 类 号：R738.1[医药卫生—肿瘤] R651.15[医药卫生—临床医学]