药物后处理的研究进展  

Study Progress on Pharmacological Postconditioning

作　　者：李豫[1] 张建福[1] 

机构地区：[1]徐州医学院生理学教研室,江苏徐州221002

出　　处：《医学综述》2009年第21期3207-3209,共3页Medical Recapitulate

摘　　要：缺血/再灌注损伤是临床常见的一种病理生理过程。缺血后处理是长时间缺血后,于再灌注前短时间内进行反复短暂的再灌和停灌,可明显减轻缺血组织和器官的再灌注损伤。药物后处理指在长时间缺血后,于再灌注前或再灌注开始的几分钟内用药,通过药物干预来减轻器官的再灌注损伤。其保护作用机制与缺血预处理、缺血后处理相似,但药物后处理更具有临床应用价值,为器官再灌注损伤的治疗提供了新策略。Ischemia/reperfusion injury is a familiar pathophysiological process in clinic. Ischemic posteonditioning applied at the onset of reperfusion following a specific prescribed algorithm is a series of brief mechanical interruptions of reperfusion, and affords protection in vivo. Pharmacological postconditioning which is defined as medicine administration before reperfusion or in the early minitues of reperfusion is a pattern against organ ischemia-roperfusion injury, Pharmacological postconditioning has similarly protective mechanism with ischemic preconditioning（ IPC ）and ischemic postconditioning（ I-PostC ）. Compared to IPC and I-PostC, Pharmacological postconditioning is more worth of clinical application, and may provide a new therapy strategy for organ reperfusion injury.

关 键 词：器官缺血 药物后处理 缺血后处理 再灌注损伤 

分 类 号：R573.39[医药卫生—消化系统]