不同类型炎症中生长因子水平差异及其意义  

Clinical significance of serum levels of growth factors in different kinds of inflammatory response.

作　　者：戴秀华[1] 赵宝春[2] 陈瑞英[3] 李素香[4] 白月民[4] 孟晋[4] 

机构地区：[1]华北煤炭医学院附属唐山妇幼保健医院儿科,063000 [2]河北医科大学唐山临床医学院急症内科 [3]华北煤炭医学院 [4]华北煤炭医学院附属医院

出　　处：《中国综合临床》2009年第11期1215-1217,共3页Clinical Medicine of China

摘　　要：目的研究感染性和自身免疫性两类炎症中血小板源生长因子（PDGF）、血管内皮生长因子（VEGF）的异常变化及变化持续时间方面的差异。方法应用ELISA法于不同时间检测149例两类炎症患者血清各因子含量值共7次，比较各因子变化情况及变化持续时间。结果PDGF：治疗前感染组（6．32±2．54）μg/ml，免疫组（2．57±1．65）μg／ml，差异有统计学意义（P〈0．05）。其组间、组内不同时间点及各组间对应时点差异均有统计学意义（P均〈0．05）。VEGF：治疗前感染组（179．5±53．30）ng／ml，免疫组（221．4±70．04）ng／ml，差异有统计学意义（P〈0．05）。其组间、组内不同时间点及各组间对应时点差异均有统计学意义（P均〈0．05）。2组生长因子水平达峰值时间[PDGF：感染组（2．6±1．1）d，免疫组（5．4±3．3）d；VEGF：感染组（2．4±0．7）d，免疫组（7．2±3．3）d]，差异均有统计学意义（P〈0．05）。异常变化持续时间PDGF：感染组（6．7±3．1）d，免疫组（15．4±6．1）d。VEGF：感染组（8．1±3．4）d，免疫组（16．7±7．2）d，差异均有统计学意义（P均〈0．05）。结论两类炎症中两种细胞因子异常变化水平及异常变化持续时间均有显著差异，这种差异与炎症的性质及结局可能有内在因果关系。Objective To evaluate the changes of platelet-derived growth factor（PDGF） and vascular endothelial growth factor（VEGF） in infectious and autoimmunity diseaases. Methods The growth factors were measured by ELISA in 149 patients for seven times in different periods,and the levels and duration were compared. Results PDGF was （6.32 ±2.54） μg/ml and （2.57 ±1.65） μg/ml（P 〈0.05） ,and VEGF was （179.5 ±53.30） ng/ml and （221.4 ± 70.04 ） ng/ml（ P 〈 0. 05 ） in the two groups before treatment; There was statistical significance in different time points between groups and within groups for PDGF（ P 〈 0. 05 ） and significant difference for time changing to the peak and changed duration between two groups for VEGF（P 〈0.05）. For the two groups,the peak time of PDGF were （2.6 ± 1.1 ） and （ 5.4 ± 3.3 ） days ; The peak time of VEGF were （2.4 ± 0. 7 ） and （ 7.2 ± 3.3 ） days respectively（P 〈0.05 for each）. However in the two groups,the change duration were （6.7 ± 3. 1 ） and （ 15.4 ± 6.1 ） days for PDGF and （8.1 ± 3.4） and （ 16.7 ± 7.2 ） days for VEGF （ P 〈 0.05 for each）. Conclusions There is significant difference for serum levels of PDGF and VEGF and the level change duration as well in the two groups, which maybe correlated with inflammatory nature and outcome.

关 键 词：血小板源生长因子 血管内皮生长因子 感染 自身免疫 

分 类 号：R363[医药卫生—病理学]