婴幼儿血管瘤患儿外周血中bFGF检测及临床意义  

Detection and Clinical Value of bFGF in the Serum of Hemangioma Infants

作　　者：张荣明[1] 王红梅[2] 王萍[3] 赵丽艳[1] 张敬[1] 

机构地区：[1]辽宁医学院附属第一医院烧伤美容整形科,辽宁锦州121001 [2]辽宁医学院附属第一医院检验科,辽宁锦州121001 [3]辽宁医学院学报编辑部,辽宁锦州121001

出　　处：《中国医科大学学报》2009年第9期692-694,共3页Journal of China Medical University

基　　金：辽宁省教育厅科学研究计划项目(2004F065)

摘　　要：目的寻找一种简单、易行的客观指标,诊断婴幼儿血管瘤及其类型,为临床治疗提供依据。方法用免疫酶标技术检测25例增生期血管瘤、14例消退期血管瘤、12例应用激素治疗后血管瘤、9例血管畸形及12例对照组患儿外周血清中碱性成纤维细胞生长因子(bFGF)的浓度。结果25例增生期血管瘤患儿外周血清中bFGF浓度明显高于应用激素治疗后血管瘤、消退期血管瘤、血管畸形及对照组;消退期血管瘤和应用激素治疗后血管瘤患儿血清中bFGF浓度略高于血管畸形及对照组,但差异无显著性。结论外周血中bFGF浓度可做为诊断婴幼儿血管瘤及其分期的重要指标,并为治疗提供依据。Objective To search an ideal and objective index that distinguish the type and phase of infantile hemangioma. Methods Enzyme-linked immunsorbent assay （ELISA） was adopted to examine the serum basic fibroblast growth facter （bFGF） concentration of 25 patients with proliferate hemangioma, 14 with involuted hemangioma, 12 with treated hemangioma by hormone,9 with vascular malformation and 12 of the control group. Results The serum bFGF concentrations of proliferate hemangioma patients were significantly higher than those of involute hemangioma,henmagioma treated by Predisone,vascular malformation patients and control group infants. Conclusion The serum bFGF concentrations may be an important index which can distinguish different type and phase of henmagioma,and may provide a scientific basis for the treatment.

关 键 词：血管瘤 免疫酶标技术 碱性成纤维细胞生长因子 

分 类 号：R732.2[医药卫生—肿瘤]