ⅠA-ⅡB期宫颈癌合并妊娠的临床预后分析  

The clinical and prognosis analysis of pregnant women with stageⅠA-ⅡB invasive cervical carcinoma

作　　者：曹莹[1] 李双[2] 张庆华[1] 胡婷[2] 王丹[2] 孟玉菡[2] 梅泉[2] 王世宣[2] 卢运萍[2] 马丁[2] 

机构地区：[1]武汉市中心医院妇产科 [2]华中科技大学同济医学院附属同济医院妇产科肿瘤分子生物学中心,湖北武汉430030

出　　处：《中国妇幼保健》2009年第32期4511-4514,共4页Maternal and Child Health Care of China

基　　金：国家重大"973"计划者合作研究基金(NO.36028029);华中科技大学创新基金(NO.HF-05-035-07-540)

摘　　要：目的:探讨ⅠA-ⅡB期宫颈癌合并妊娠的临床病理特征、治疗及预后情况。方法:对1999年4月～2007年6月收治的9例ⅠA-ⅡB期宫颈癌合并妊娠患者的临床资料做回顾性分析(研究组),并以同期治疗的40岁以下非妊娠期ⅠA-ⅡB期宫颈浸润癌患者45例作为对照组,分析两组的临床预后情况。结果:研究组与对照组在临床特征、临床分期、病理类型、组织学分级、盆腔淋巴结转移、手术方式及预后相关因素等方面相比无统计学差异(P>0.05);两组的总体生存率和无瘤生存率相比也均无统计学差异(P>0.05)。结论:妊娠不影响宫颈癌的发展,其手术和放疗方案基本与普通宫颈癌相同,预后也无明显差异,可根据临床期别及对生育的要求,制定个体化治疗方案。Objective：To study the clinical characteristics,pathological characteristics,treatment and prognosis of pregnant women with stageⅠA-ⅡB invasive cervical carcinoma.Methods：The pregnant patients（N=9） and non-pregnant women（N=45） with stageⅠA-ⅡB invasive cervical carcinoma were recruited from Apr.1999 to Jun.2007.The clinical information,including clinical,pathological and prognostic characteristics,was retrospectively analyzed.Results：There was no significant difference between the two groups in clinical characteristics,clinical staging,pathological categories,histological classification,metastasis of lymph nodes,treatment,and correlation factors of prognosis,as well as overall and recurrence-free survival rates（P〉0.05）.Conclusion：The pregnant patients with cervical cancer do not appear to have a more aggressive clinical course and prognosis,whose treatment of surgery and radiotherapy is as the same as non-pregnant patients with cervical cancer.Individual therapeutic schedules should be made according to clinical staging of cervical cancer and fertility requirement of patients.

关 键 词：宫颈癌 妊娠 病理特征 预后 

分 类 号：R737.33[医药卫生—肿瘤]