早期经历影响个体成年后行为的表观遗传学机制  

The Role of Epigenetic Regulation in How Early Life Experience Influences Adult Behaviors

作　　者：李婷[1] 朱熊兆[1] 

机构地区：[1]中南大学湘雅二医院医学心理研究中心,长沙410011

出　　处：《心理科学进展》2009年第6期1274-1280,共7页Advances in Psychological Science

基　　金：国家自然科学基金资助项目(30670710);湖南省自然基金项目(09JJ6030);教育部留学回国人员科研启动基金项目资助

摘　　要：既往研究已证实早期经历与个体成年后的行为密切相关,然而早期经历对个体成年后的行为产生长期影响的分子生物机制并不清楚。近年来越来越多的研究表明表观遗传因素在早期经历调控成年个体行为中发挥了重要功能。表观遗传是研究没有DNA序列变化,但是可遗传和可逆转的基因组功能的调控。本文试图从早期经历参与调控个体成年后行为表现以及基因表达的相关表观遗传学修饰进行综述。Behaviors of human and animals in adulthood is influenced greatly by the experience of its early life in childhood, however, it is still unclear of the molecular mechanisms. Recent researches showed that epigenetic alternation of individuals in its early life contribute to the behavior change of grownup. Epigenetics involves in the heritable but reversible regulation of various gene expression through DNA methylation and chromatin modification without sequence alternation. This article briefly introduced the epigenetic mechanisms which contibuted to gene regulation and behavior change of adult individuals caused by early life experience.

关 键 词：早期经历 表观遗传学 DNA甲基化 HPA轴 

分 类 号：B844[哲学宗教—发展与教育心理学] B845[哲学宗教—心理学]