大鼠原位肠-肝灌流模型研究概况  

Methodology overview of perfused rat intestine-liver preparation

作　　者：王怡薇[1] 梁日欣[1] 杨伟鹏[1] 王彦礼[1] 翁小刚[1] 杨庆[1] 王岚[1] 朱晓新[1] 

机构地区：[1]中国中医科学院中药研究所,北京100700

出　　处：《中国中药杂志》2009年第21期2701-2703,共3页China Journal of Chinese Materia Medica

基　　金：中医药行业科研专项(200807036);中国中医科学院基本科研业务费自主选题项目(ZZ2006114)

摘　　要：大鼠原位肠-肝灌流模型被认为在研究药物的吸收、代谢和首过效应方面具有独特的优势。本文对该模型的方法、应用和前景进行综述。Since pang set up the perfused rat intestine-liver preparation and applied it to study the disposition of enalapril, this model has been widely considered to have the particularly advantage in studying the absorption, metabolism and first-pass effect. Now the methods and applications are to be reviewed and the perspective is to be discussed.

关 键 词：肠-肝灌流 首过效应 

分 类 号：R363[医药卫生—病理学]