伽玛刀治疗听神经瘤的临床研究  

Clinical study of gamma knife for acoustic neuromas

作　　者：任保刚[1] 杨卫忠[1] 石松生[1] 倪天瑞[1] 梁日生[1] 陈建乐[1] 王锐[1] 宋施委[1] 庄冰[1] 

机构地区：[1]福建医科大学附属协和医院神经外科,伽玛刀治疗中心,福州350001

出　　处：《立体定向和功能性神经外科杂志》2009年第5期282-284,共3页Chinese Journal of Stereotactic and Functional Neurosurgery

摘　　要：目的旨在进一步提高伽玛刀治疗听神经瘤的效果。方法应用OUR-XGD旋转式伽玛刀治疗听神经瘤115例,男性45例,女性70例,年龄19～83岁,肿瘤直径5～40mm,采用多个放射中心联合照射,周边等剂量曲线为30%～50%,周边照射剂量10～13Gy,平均12Gy。结果随访96例,随访12～73个月,MR复查提示50例肿瘤缩小,43例无变化,3例增大;31例肿瘤中心失增强。无面瘫和面部麻木,听力保留52%。结论伽玛刀作为一种无创的治疗方法,对于中小型听神经瘤的治疗是一个比较好的选择。Objective To improve the results of gamma knife for acoustic neuromas.Methods 115 patients with acoustic neuromas were treated with Rotating Gamma System,Male 45,female 70.The age of the patients ranged from 19 to 83 years.The tumor diameter ranged from 5 to 40 mm.Multi-isocenter dose planning placed a marginal dose of l0 to 13 Gy（mean,12Gy）to the 30% to 50% peripheral isodose line.Results Follow-up ranged from 12 to 72 months in 96 patients.patients,tumor size reduced in 50,remained unchanged in 43,and increased in 3,a loss of central enhancement was demonstrated on MRI in 31 cases.No patient developed new facial paralysis or facial numbness.The preservation rate of functional hearing was 52%.Conclusion Gamma knife radiosurgery remains a noninvasive treatment option,it provided a better choice for patiens with small and medium sized acoustic neuromas.

关 键 词：听神经瘤 立体定向放射外科 伽玛刀 

分 类 号：R739.41[医药卫生—肿瘤]