晚期乳腺癌术前区域性动脉灌注化疗后微血管密度及微淋巴管密度的变化  

Effect of preoperative regional intra-arterial infusion chemo-therapy on MVD and LMVD in advanced breast can-cer

作　　者：马小军[1,2] 蒲永东[1] 何建苗[1] 赵秀坤[2] 

机构地区：[1]解放军总医院第二附属医院普外科,北京100091 [2]空军指挥学院医院外科,北京100097

出　　处：《中华乳腺病杂志（电子版）》2007年第3期24-27,共4页Chinese Journal of Breast Disease(Electronic Edition)

摘　　要：目的探讨术前区域动脉灌注化疗及全身静脉化疗对晚期乳腺癌微血管密度(MVD)、微淋巴管密度(MLVD)的影响。方法将76例晚期乳腺癌患者随机分为2组,术前动脉灌注化疗组35例,术前全身静脉化疗组41例,选其中25例化疗前的乳腺癌患者作对照组。采用免疫组化SP法,用CD34、VEGFR3抗体对3组乳腺癌组织标本进行MVD、MLVD检测。结果术前动脉灌注化疗组的MVD为36.05±13.64,全身静脉化疗组为49.92±12.90,对照组为60.38±13.54,各组间比较(P<0.01);术前动脉灌注化疗组的MLVD为6.62±3.70,全身静脉化疗组为9.96±4.57,对照组为11.30±5.32,动脉灌注化疗组与对照组比较显著下降(P<0.01),与静脉化疗组比较差异有统计学意义(P<0.05),静脉化疗组与对照组比较差异无统计学意义(P>0.05)。结论术前区域性动脉灌注化疗比全身静脉化疗更能有效降低肿瘤组织及其周边组织内MVD和MLVD,从而抑制肿瘤细胞生长,减少肿瘤转移的机会。Objective To investigate the different effect between preoperative regional intra-arterial infusion chemotherapy and preoperative intra-venous infusion chemotherapy on microvessel density （MVD） and lymphatic microvessel density （LMYD） in advanced breast cancer. Methods Seventy-six breast cancer patients were divided into 2 groups ： the preoperative regional intra-arterial infusion Chemotherapy group （PIAC group,35 cases）, and the preoperative intra-venous infusion chemotherapy group （PIVC group,41 cases） ; and another 25 breast cancer patients without preoperative chemotherapy were as the control group. Using SP immunostaining method, MVD and LMVD of the samples of breast cancer in the 3 groups were detected with CD34 and VEGFR3. Results MVD was 36.05± 13.64 in the PIAC group, 49.92 ±12.90 in the PIVC group and 11.30± 5.32 in the control group; there was a significant difference in comparison of the 3 groups（P〈0.01）. MLVD was 6.62 ±3.70 in the PIAC group, 9.96 ±4.57 in the PIVC group and 11.30 ±5.32 in the control group, it was remarkably decreased in the PIAC group compared with the control group, there was a significant difference between the two groups （P 〈0.01 ）, the difference between the PIAC group and the PIVC group was statistically significant （P 〈0.05） ,while the difference between the PIVC group and the control group was not statistically significant （P 〉 0.05）. Conclusian PIAC can more effectively reduce MVD and MLVD than PIVC, thus restraining the growth of cancer cells and reducing cancer metastasis.

关 键 词：乳腺癌 动脉灌注化疗 微血管密度 淋巴管密度 

分 类 号：R737.9[医药卫生—肿瘤]