朗格罕细胞和 p53 蛋白与喉癌中人乳头瘤病毒感染的关系  

Association of Langerhans′ Cell and p53 with HumanPopillomovirous Infection in Human Laryngeal Carcinoma

作　　者：李瑞琴[1,2] 李惠翔[1,2] 高冬玲[1,2] 张云汉[1,2] 

机构地区：[1]河南中医学院病理教研室 [2]河南医科大学病理教研室

出　　处：《河南医学研究》1998年第3期216-218,共3页Henan Medical Research

摘　　要：目的：研究喉癌的发生机理。方法：应用免疫组化ＬＳＡＢ法对３０例喉鳞状细胞癌中人乳头瘤病毒（ＨＰＶ）、ｐ５３蛋白、朗格罕细胞（Ｌａｎｇｅｒｈａｎｓｃｅｌ，ＬＣ）进行了染色。结果：ＨＰＶ感染的癌旁粘膜内ＬＣ的数量明显少于无感染者，ｐ５３蛋白表达率（３７３％）也明显低于无感染组（８３３３％）。结论：ＨＰＶ、ＬＣ、ｐ５３是与喉癌发生有关的三个重要因素，且三者相互影响。喉癌的发生机理可能是由于ＨＰＶ感染引起ＬＣ减少，局部免疫功能降低和其它改变；ＨＰＶ感染还可能通过表达的某种肿瘤蛋白使ｐ５３失活而致癌。Objective: To study the carcinogenesis of laryngeal carcinoma.Methods: Human popilloma virous (HPV)、p53 protein and Langerhans cell (LC) were stained in 30 cases of sqamous cell carcinoma of laryhx by LSAB immunohistochmical technique.Results: The amount of LCs in Pericarcinoma mucosa with HPV infection was much less than that without HPV infections.The rate of p53 expression in HPV infected group was 37.5%,and is significantly lower than that in no HPV infected grouping (83.33%).Conclusion: HPV,LC and p53 gene are three important factors involved in carcinogenesis of laryngeal carcinoma,and interact on each other.The mechanism may be that HPV infection result in LC reducing and deficit of local immune function and other wise.HPV inactiate the p53 gene through expression certain kind of tumor protein.

关 键 词：人乳头瘤病毒 朗格罕细胞 P53蛋白 喉癌 

分 类 号：R739.65[医药卫生—肿瘤]