超氧化物歧化酶和脂质过氧化物与溃疡病发病关系  

Role of Superoxide Dismutase and Lipid Peroxide in thePathogenesis of Peptic Ulcer Disease andEffects of Ulcer-Healing Drugs

作　　者：周天星[1,2] 李建生[1,2] 王进[1,2] 李月白[1,2] 邢陆伟[1,2] 油书恒[1,2] 

机构地区：[1]河南医科大学第一附属医院消化内科 [2]河南医科大学生物化学教研室

出　　处：《河南医学研究》1998年第3期228-230,共3页Henan Medical Research

基　　金：河南省医学科学院科研基金

摘　　要：目的：观察超氧化物歧化酶（ＳＯＤ）和脂质过氧化物（ＬＰＯ）在消化性溃疡（ＰＵ）治疗前后变化，以探索其对ＰＵ发病和愈合作用。方法：用ＳＵＮ法和于树玉法分别测定ＰＵ患者血及组织中铜锌超氧化物歧化酶（ＣｕＺｎＳＯＤ）活性和ＬＰＯ含量。结果：１８０例十二指肠溃疡（ＤＵ）和４２例胃溃疡（ＧＵ）患者粘膜和红细胞中ＣｕＺｎＳＯＤ活性比正常组显著降低（Ｐ＜０．０１～０．００１）。１３６例ＤＵ组织及血中和１５例ＧＵ组织中ＬＰＯ含量比正常组显著升高（Ｐ＜００１～０．００１）。用呋喃唑酮、雷尼替丁和洛赛克分别治疗５０、２０和２４例ＤＵ患者两周后组织中ＣｕＺｎＳＯＤ活性比治疗前明显升高（Ｐ＜０．０１～０．００１）。组织中ＬＰＯ含量比治疗前明显降低（Ｐ＜０００５～０．００１）。组织和红细胞中ＣｕＺｎＳＯＤ活性从活动期→愈合期→瘢痕期逐渐升高，而ＬＰＯ含量则逐渐降低。结论：粘膜组织中ＣｕＺｎＳＯＤ活性和ＬＰＯ含量升降与消化性溃疡的愈合和发病密切相关。Objective:In order to research role of superoxide dismutase (SOD) and lipid peroxide(LPO) in Pathogenesis of peptic ulcer.Methods:Cu-Zn-SOD activityandLPOlevels in mucosaltissue and blood were ditermined in 222 patients with peptic ulcer and 128 controls,which were also repeated in 96 DU cases after the treatment by furazolidone(52)ranitidine(20)and omeprazole (24),respectively,for 2 wks.Cu-Zn-SOD activity was determined with adrenaline autoxidation method according to SUN's.LPO levels was determined according to Yu's method.Results:SOD was significantly lower,and LPO significantly higher in both blood and mucosa of ulcer patients than those of normal controls(P<0.01～0.001)　the mucosal SOD was significantly increased and LPO significantly decreased than the pretreatment levels in all of the regime groups.It was also show that during the course of ulcer healing,SOD progressively but significantly increased from active to healing to scaring stages,the opposite was ture for LPO.Conclusion:These results suggest that mucosal SOD and LPO levels are closely related to the pathogenesis and healing of peptic ulcer.

关 键 词：超氧化物歧化酶 脂质过氧化物 消化性溃疡 

分 类 号：R573.1[医药卫生—消化系统]