根治Hp对预防老年十二指肠溃疡再出血的临床价值  

Clinical signification of helicobacter pylori eradication in reducing rebleeding in elderly duodenal ulcer patients

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作  者:冯德辉[1] 黄丰[1] 周宇[1] 

机构地区:[1]广东医学院附属医院老年病科

出  处:《实用老年医学》1998年第4期165-166,共2页Practical Geriatrics

摘  要:目的观察根除Hp对老年人十二指肠溃疡再出血的影响。方法选择70例Hp感染十二指肠溃疡并出血的老年病人并随机分成A、B2组。A组应用奥美拉唑(洛赛克)、胶态次枸橼酸铋(德诺)胶囊和羟氨苄青霉素进行根除Hp治疗;B组单独用洛赛克治疗。4周后停药追踪观察18个月。结果2组溃疡愈合率分别为100%、96.1%,2者比较无显著性差异(P>0.05);A、B2组Hp根除率分别为85%和16.6%,2者比较有显著性差异(P<0.05)。随访18个月后,A、B2组再出血率分别为2.94%和28%,2者比较有显著性差异(P<0.05)。结论根除Hp对老年人十二指肠溃疡再出血有一定的预防作用。Objective To study the rates of rebleeding in the aged duodenal ulcer patients following eradication of H.pylori. Methods 70 elder patients with associatedH.pylori duodenal ulcer hemorrhage were randomly divided into two groups.The patients received Losec,DeNol plus Amoxicillin(Group A),or Losec alone(Group B)for 4 weeks.They were followed up for 18 months. Results The ulcer healing rates were 100%(Group A)and 967%(Group B);there was no significant difference between the two groups (P>005).H.Pylori eradication rates were 85%(Group A)and 166%(Group B).H.pylori eradication rates of Group A were significantly higher than that of Group B(P<005).Rebleeding rates were significantly lower in Group A(294%) than in Group B(P<005). Conclusion Eradication of H.pylori significantly reduces the rates of rebleeding in the aged duodenal ulcer patients.

关 键 词:十二指肠溃疡 出血 幽门螺杆菌 治疗 

分 类 号:R573.105[医药卫生—消化系统]

 

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