一种组织工程材料的制备及性能表征  

The Preparation and Characterization of a Material for Bone Tissue Engineering

作　　者：苏健裕[1] 陈玲[1] 杨连生[1] 李晓玺[1] 余龙[1] 

机构地区：[1]华南理工大学轻化工研究所,广东广州510640

出　　处：《高分子材料科学与工程》2009年第11期125-128,共4页Polymer Materials Science & Engineering

基　　金：国家自然科学基金国际合作与交流项目(50540420129);武器装备预研基金项目(9140A12060206JW1602);广东省自然科学基金团队项目(05200617)

摘　　要：以异氰酸酯(MDI)作为相容剂,采用共混挤出技术制备不同百分含量的聚己内酯(PCL)与淀粉的共混产物(SPCL)作为研究对象,对材料的力学性能、组成、微观结构、结晶性质和热性能进行表征,重点考察了材料的亲水性能和降解性能。结果表明,MDI明显改善了淀粉和PCL两相的相容性,淀粉的存在增加了SPCL羟基基团的数量,降低了材料的力学性能,同时抑制了PCL的结晶,降低了材料的熔点,提高了材料亲水性能,加快了材料在Hank′s平衡盐溶液(HBSS)中的降解速度。表明SPCL是一种有广泛应用前景的组织工程植入修复材料。Starch/polycaprolactone （SPCL） blends were prepared by blending extruder with methylenediphenyl diisocyanate （MDI） as a compatibilizer. Its effect on the resultant mechanical and microstructure properties of the blends were studied by mechanical testing, FT-IR, SEM, XRD, and DSC. Its contact angle and biodegradation in Hank＇s balanced salt solution （HBSS）were also detected. The results show that MDI can improve significantly the phases of PCL and starch, but the mechanical properties of the SPCL blends are decreased and the hydroxyl group are increased by adding starch. The crystallization of PCL is also suppressed by blending starch, and Tins of SPCL are decreased, but the hydrophilicity and degradation in HBSS are increased. This work shows that SPCL presents a great potential application in biomedical materials, and the research provides preliminary data for SPCL blends to be used in the field of tissue engineering strategy.

关 键 词：聚己内酯 淀粉 共混物 骨组织工程 支架材料 

分 类 号：TB39[一般工业技术—材料科学与工程]