聚丙交脂-乙交酯纤维的温压成形  

Poly(lactic acid-glycolic acid)(PLGA)fiber material fabricated by mild temperature molding

作　　者：陈剑[1] 易磊[1] 樊新[1] 阮建明[1] 刘莹[1] 周智华[1] 周忠诚[1] 邹俭鹏[1] 

机构地区：[1]中南大学粉末冶金国家重点实验室,湖南长沙410083

出　　处：《中南大学学报（自然科学版）》2009年第5期1222-1227,共6页Journal of Central South University:Science and Technology

基　　金：国家自然科学基金资助项目(50774096;50604017)

摘　　要：通过溶液沉析纺丝法制备聚丙交酯乙交酯(PLGA)纤维,观察纤维的形貌并对其进行XRD和SEM表征。采用纤维温压成形法控制压力和温度得到条形的PLGA材料结合试样断口分析,研究成型压力与温度对PLGA材料的力学性能的影响。研究结果表明:非晶多孔结构的PLGA纤维可通过溶液沉析纺丝的方法获得,其孔径为0.1～1.0μm;压制压力和压制温度对材料的力学性能影响较大,材料的抗弯强度、剪切强度和抗弯模量均随着温度和压力的增大而先增大后降低;在压制压力为105MPa,压制温度为160℃时,试样的力学性能比较理想,此时,其抗弯强度可达到187.3MPa,剪切强度达到100.1MPa,抗弯模量达到2.5GPa,可望作为非承重部位骨折愈合内固定材料。Solvent spinning method was used to prepare Poly（lactic acid-glycolic acid）（PLGA）fiber.The fiber was observed by X-ray diffractometry（XRD）and scanning electron microscope（SEM）.PLGA rectangular materials were fabricated by fiber mild temperature molding and the effects of molding pressure and temperature on the mechanical strength of PLGA were also investigated.The results show that the amorphous PLGA fiber with porous structure（0.1 1.0 μm）is obtained by diluted solvent spinning method and the mechanical properties is affected by pressure and temperature.Bending strength and shearing strength of the samples increase firstly and then decrease with the increase of molding temperature and pressure.While the molding temperature is 160 ℃and the pressure is 105MPa,the PLGA materials possess optimal mechanical properties,bending strength,shearing strength and bending modulus 187.3 MPa,100.0 MPa and 2.5 GPa,respectively.The mild temperature molding PLGA materials are desired to play a grate role in non-bearing internal fixation devices.

关 键 词：溶液沉析纺丝 聚丙交脂-乙交酯纤维 温压成形 力学性能 

分 类 号：R318.08[医药卫生—生物医学工程] TB324[医药卫生—基础医学]