肝动脉热化疗及热碘油栓塞治疗结肠直肠癌肝转移  

Transcatheter hepatic arterial thermo-chemotherapy and thermo-lipiodol embolization for the treatment of hepatic metastases from colorectal carcinoma

作　　者：王煊[1] 陈小飞[1] 

机构地区：[1]淮安市南京医科大学附属淮安第一医院介入科,223300

出　　处：《介入放射学杂志》2009年第10期737-739,共3页Journal of Interventional Radiology

基　　金：江苏淮安市科技局(HASO4030)

摘　　要：目的评价肝动脉热化疗及热碘油栓塞治疗结肠直肠癌肝转移瘤的效果。方法68例结肠直肠癌肝转移瘤患者分为2组,采用肝动脉热化疗及热碘油栓塞治疗的34例作为热疗组,采用常温动脉化疗及碘油栓塞治疗的34例作为常规组。结果热疗组有效率为65%(22/34),常规组有效率为32%(11/34),两组间差异有统计学意义。两组术后肝功能变化差异无统计学意义。6、12、18和24个月生存率热疗组分别为100%、82%、44%和18%,常规组分别为91%、47%、15%和6%。结论肝动脉热化疗及热碘油栓塞治疗结肠直肠癌肝转移是一种有效的方法,而对肝功能无明显的损害。Objective To evaluate the clinical efficacy of transcatheter hepatic arterial thermochemotherapy and thermo-lipiodol embolization in the treatment of hepatic metastases from coloreetal carcinoma. Methods Sixty-eight cases with hepatic metastases from colorectal carcinoma were equally and randomly divided into two groups. The patients in study group were treated with transcatheter hepatic arterial thermo-chemotherapy and thermo-lipiodol embolization, while the patients in control group were treated with conventional （normal temperature） transcatheter hepatic arterial chemotherapy lipiodol embolization. Results The effective rate of study group and control group was 65% （22/34） and 32%（11/34） respectively, the difference between two groups was statistically significant （P 〈 0.05）. No significant difference in the postoperative changes of hepatic function tests was found between the two groups. The survival rate at 6, 12, 18 and 24 months after the treatment was 100%, 82%, 44% and 18% respectively in study group, while it was 91%, 47%, 15% and 6% respectively in control group. Conclusion Transcatheter hepatic arterial thermo-chemotherapy and thermo-lipiodol embolization is an effective and safe treatment for the hepatic metastases from colorectal carcinoma and has no obvious damage to the hepatic function. （J Intervent Radiol, 2009, 18： 737-739）

关 键 词：结直肠癌 肝转移瘤 热化疗 放射学/介入性 

分 类 号：R735.3[医药卫生—肿瘤]