青年肝癌患者术前中性粒细胞与淋巴细胞比值与预后的相关性  

Correlation of preoperative neutrophil-to-lymphocyte ratio to prognosis of young patients with hepatocellular carcinoma

作　　者：郭智兴[1,2] 韦玮[1,2] 钟崇[1,2] 石明[1,2] 陈敏山[1,2] 郭荣平[1,2] 

机构地区：[1]华南肿瘤学国家重点实验室,广东广州510060 [2]中山大学肿瘤防治中心肝胆科,广东广州510060

出　　处：《癌症》2009年第11期1203-1208,共6页Chinese Journal of Cancer

基　　金：广东省科技计划项目(No.2006B36002013)~~

摘　　要：背景与目的:中性粒细胞与淋巴细胞比值(neutrophil-to-lymphocyte ratio,NLR)作为炎症反应评价指标,已被认为是肝癌的预后因素。本研究探讨接受根治性手术的青年肝癌患者术前NLR与预后的相关性。方法:回顾性分析91例2000-2005年间诊断为原发性肝细胞肝癌,年龄小于35周岁,并接受根治性切除术的患者临床资料,根据患者术前外周静脉血NLR大小分为低NLR组(NLR≤2)和高NLR组(NLR>2),分析两组患者NLR与各自的无瘤生存时间、总生存时间之间的关系。结果:低NLR组患者1年、3年无瘤生存率为85.3%和80.0%,总生存率为92.9%和85.6%;高NLR组患者1年、3年无瘤生存率为69.1%和43.5%,总生存率为89.8%和57.1%,组间差异有统计学意义(P<0.01)。Cox回归模型提示术前NLR>2和肿瘤大小是青年肝癌患者无瘤生存和总生存的危险因素。结论:NLR>2是达到Ⅲ级根治切除标准青年肝癌患者的预后危险因素。Background and Objective. As an index of inflammation, neutrophil-to-lymphocyte ratio （NLR） is regarded as one of prognostic factors of hepatocellular carcinoma （HCC）. This study was to evaluate the correlation of preoperative NLR to the prognosis of young HCC patients after radical resection. Methods： Clinical data of 91 HCC patients with age of younger than 35 years who underwent radical resection from 2000 to 2005 were analyzed. According to preoperative NLR, the patients were divided into the low NLR group （NLR≤2） and the high NLR group （NLR〉2）. The overall and disease-free survival rates of the two groups were compared.Results： The 1- and 3-year overall survival rates were 92.9% and 85.6% in the low NLR group, 89.8% and 57.1% in the high NLR group; the 1- and 3-year disease-free survival rates were 85.3% and 80.0% in the low NLR group, 69.1% and 43.5% in the high NLR group. The difference between the two groups was significant （P〈0.05）. Cox multivariate analysis showed that preoperative NLR and tumor size were independent prognostic factors of disease-free survival and overall survival for young HCC patients after radical resection. Conclusion： Preoperative NLR 〉2 was a negative prognostic factor of disease-free and overall survival for young HCC patients after radical resection.

关 键 词：肝肿瘤 中性粒细胞与淋巴细胞比值 外科手术 预后 

分 类 号：R735.7[医药卫生—肿瘤]