接骨七厘散软胶囊内容物加PEG400湿法超微粉碎工艺研究  

Frequent Vibrating Pulverization for the Content of Jie Gu Qi Li San Soft Capsule by Wet Processing with PEG 400

作　　者：孔令提[1] 代龙[1] 

机构地区：[1]山东中医药大学,山东济南250355

出　　处：《时珍国医国药》2009年第11期2810-2812,共3页Lishizhen Medicine and Materia Medica Research

基　　金：山东省中医管理局项目(No.2005-180)

摘　　要：目的湿法超微粉碎技术对接骨七厘散工艺改进和剂型改革,考察接骨七厘散软胶囊内容物的最佳湿法超微粉碎工艺参数。方法以物料粒度(D50和D90)、物料稳定性等作考察指标,采用单因素考察法分别对分散介质、介质用量等工艺参数进行筛选。结果软胶囊内容物的最佳湿法超微粉碎工艺为:加1.5倍量预保温PEG400,40℃以下超微粉碎35m in,出料,即得。结论湿法超微粉碎工艺简便,效率高,不仅使物料粒度变细提高了药物生物利用度,节省药源,同时使物料均质化程度更高,便于制剂,具有广阔的应用前景。Objective To explore the optimal ultra-fine pulverization procedure for the content of Jie Gu Qi Li San soft capsule by wet processing.Methods Using the particle size（D50 and D90）,station and so on of the contents from Jie Gu Qi Li San soft capsule as main indicators,the pulverization progress was studied by single factor method.In this way,the effects of such conditions as pulverizing time,mediator consumption,pulverizing temperature and so on extracting rate were investigated.Results The optimal pulverization procedure for the content of Jie Gu Qi Li San soft capsule was 1.5 times of PEG400, vibrating frequently 35 minutes under 40℃. Conclusion The optimum pulverizing procedure is convenient, and applicable to the preparation of Jie Gu Qi Li San Soft Capsule. It should have a good future.

关 键 词：接骨七厘散软胶囊 湿法超微粉碎 PEG400 生物利用度 

分 类 号：R283[医药卫生—中药学]