羟苯磺酸钙联合包醛氧淀粉治疗慢性功能衰竭的临床观察  

Efficacy of Calcium Dobesilate combined with Oxyamyli Aldehydum Tectum in Treating Chronic Renal Failure

作　　者：熊重祥[1] 邹和群[1] 王新华[1] 胡静[1] 樊晓红[1] 

机构地区：[1]上海市第七人民医院,上海200137

出　　处：《国际泌尿系统杂志》2009年第6期727-729,共3页International Journal of Urology and Nephrology

摘　　要：目的观察羟苯磺酸钙联合包醛氧淀粉治疗慢性肾功能衰竭的疗效及安全性。方法60例患者随机分为两组，在常规治疗基础上，治疗组给予羟苯磺酸钙0．5g，3次／日，同时给予包醛氧淀粉组5g，3次／日，治疗8周。对照组给予包醛氧淀粉5g，3次／日，而不给予羟苯磺酸钙，治疗8周。两组患者治疗前后检测血尿素氮、血清肌酐和转氨酶、血钙、血磷等指标。观察两组患者临床疗效及副反应。结果治疗组BUN及血肌酐水平较对照组显著降低（P〈0．01）；两组患者服用药物前后肝功能无显著变化，P〉0．05。两组患者未观察到明显副作用。结论羟苯磺酸钙与包醛氧淀粉联合能有效改善慢性肾功能衰竭患者肾功能且具有安全性。Objectives To observe the efficacy and security of combined treatment with Calcium Dobesilate and Oxyamyli Aldehydum Tectum in patients with chronic renal failure. Methods 60 CRF patients were divided into two groups. On the base of routine therapy, patients in study group administered Calcium Dobesilate at a dose of 0.5 g, tid, and Oxyamyli Aldehydum Tectum at a dose of 5 g, tid, simultaneously for 8 weeks, and patients in con- trol group administered Oxyamyli Aldebydum Tectum at the same dose and for the same term but no Calcium Dobesilate. The levels of blood urea nitrogen （ BUN）, serum creatinine （ Scr）, liver function, serum calcium and phosphorus were measured before and after treatment. Clinical efficacy and side effects in the two groups were followed - up. Results BUN and Scr levels in study group were significantly reduced, compared to controls （ p 〈 0.01 ）. There were no significant difference between the liver function before and after treatment either in study group and controls, both p 〉 0.05. No obvious side effect was observed in each group. Conclusions Therapy with Calcium Dobesilate combined with Oxyamyli Aldehydum Tectum might be one of the effective and safe methods for the treatment of CRF patients.

关 键 词：肾功能衰竭 慢性 淀粉 

分 类 号：R692.5[医药卫生—泌尿科学]