注射用薏苡仁油防治蒽环类药物化疗相关心脏不良反应的临床观察  

Clinical observation on the prevention of anthracycline-associated cardiotoxicity by Semen coicis oil injection

作　　者：文彩虹[1,2] 许新华[1] 周政涛[2] 鲁明骞[2] 冯晓庆[1] 

机构地区：[1]三峡大学第一临床医学院,宜昌443003 [2]宜昌市中心人民医院肿瘤科,宜昌443003

出　　处：《肿瘤》2009年第10期1003-1005,共3页Tumor

摘　　要：目的:观察注射用薏苡仁油对肿瘤患者行蒽环类(anthracycline,ATC)药物化疗引起的心脏不良反应的防治作用。方法:88例接受ATC化疗的恶性肿瘤患者随机分为实验组和对照组。实验组44例,在化疗同时给予注射用薏苡仁油注射液200mL静脉滴注,每天1次,连用2周;对照组44例,仅接受化疗而不使用注射用薏苡仁油。治疗前后检查心电图和超声心动图中的左心室舒张末期内径(lef tventricular internal diameter in diastole,LVDd)、左心室收缩末期内径(left ventricular internal diameter in systole,LVDs)、舒张早期与晚期充盈速度比值(E/A)、射血分数(ejection fraction,EF)和短轴缩短率(fraction of shortening,FS)等各项指标。结果:化疗后实验组与对照组EF和FS的差异无统计学意义(P>0.05),而LVDd、LVDs和E/A及心电图异常改变的差异有统计学意义(P<0.05)。结论:注射用薏苡仁油对ATC所导致的急性心脏不良反应有一定的防治作用。Objective：To evaluate the protective effects of Semen coicis oil injection against anthracycline-associated cardiotoxicity. Methods：Eighty eight patients who received anthracycline-based chemotherapy were randomized into test group （n=44） and control group （n=44）. The patients in the test group received chemotherapy and 200 mL Semen coicis oil injection every day for 2 weeks and the patients in the control group only received chemotherapy. Electrocardiogram （ECG） and echocardiogram including left ventricular internal diameter in diastole （LVDd）,left ventricular internal diameter in systole （LVDs）,E/A,ejection fraction （EF）,fraction of shortening （FS） were measured to evaluate the cardiac function.Results：There was no statistical difference in EF and FS between the two groups,but the differences in LVDd,LVDs,E/A,and abnormal ECG changes were statistically significant between the two groups.Conclusion：The Semen coicis oil injection prevents the occurrence of acute cardiotoxicity associated with anthracycline.

关 键 词：肿瘤 药物疗法 蒽环类 药物毒性 心脏 薏苡仁油 静脉注射用 

分 类 号：R730.53[医药卫生—肿瘤]