口腔黏膜癌中HIF-1a、VEGF表达与血管生成关系的研究  

Relationship between the Expression of HIF-1a and VEGF and Angiogenesis in Oral Mucosa Carcinoma

作　　者：赵尔杨[1] 王姗[1] 施磊[1] 方明[2] 徐欣[1] 

机构地区：[1]哈尔滨医科大学附属第一医院口腔病理科,黑龙江哈尔滨150001 [2]哈尔滨医科大学研究生学院

出　　处：《口腔医学研究》2009年第5期545-547,共3页Journal of Oral Science Research

基　　金：黑龙江省教育厅课题(编号:10531113)

摘　　要：目的:探讨口腔黏膜癌组织中缺氧诱导因子-1a(hypoxia-inducible factor1alpha,HIF-1a)及血管生成因子VEGF的表达及其与微血管密度(microvessel densitity,MVD)、临床病理因素之间的关系。方法:采用免疫组化链霉素抗生物素蛋白-过氧化物酶(SP法)检测30例口腔黏膜癌组织中的HIF-1a、VEGF和CD34的表达。结果:HIF-1a、VEGF的表达与肿瘤MVD的表达呈正相关(P<0.05),HIF-1a、VEGF表达与肿瘤组织学分化程度呈负相关;与淋巴结转移成正相关;与肿瘤的浸润深度无关。结论:口腔黏膜癌中HIF-1a、VEGF的异常高表达与MVD呈正相关,且两者可视为影响口腔黏膜癌预后的因素。Objective ： To explore the expression of HIF - 1 a （ hypoxia - inducible factor 1 alpha） and VEGF （ vascular endothelial growth factor） in oral mucosa carcinoma tissue and its correlation with MVD （microvessel density） and clinical pathological factors. Methods： We adopted immunohistochemistry streptomycin avidin peroxidase （sp method） to detect the expression of HIF - 1 a, VEGF and CD34 in 30 cases of oral mucosa carcinoma tissue. Results： The expression of HIF -1a and VEGF had positive correlation with the expression of MVD in tumor tissue（ P 〈 0.05 ）, and negative correlation with the differentiation degree of tumor tissue. It had positive correlation with lymph node metastasis, but no correlation with invasive depth. Conclusion： The abnormal high expression of HIF - 1 a and VEGF has positive correlation with MVD, and both of them could be considered as the factors which influence the prognosis of oral mucosa carcinoma.

关 键 词：口腔黏膜癌 缺氧诱导因子-1a 血管生成因子 微血管密度 血管形成 

分 类 号：R739.8[医药卫生—肿瘤]