经回肠-门静脉置入IDDS术治疗肝肿瘤的临床研究  

Investigation of inserting implantable drug delivery system for hepatoma through ileum-portal vein

作　　者：周文波[1,2] 袁方均[2] 孙少华[2] 胡洪生[2] 戴宗晴[2] 郑启昌[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院肝胆外科,湖北武汉430022 [2]郧阳医学院附属东风医院普通外科,湖北十堰442008

出　　处：《中国现代普通外科进展》2009年第9期780-782,共3页Chinese Journal of Current Advances in General Surgery

摘　　要：目的:探讨经回肠-门静脉置入埋植式给药装置(IDDS)化疗肝肿瘤的新方法。方法:157例肝肿瘤患者中行回肠-门静脉置入IDDS术134例,导管头端置于门静脉主干及以上部位;行肝动脉化疗栓塞术(TACE)联合回肠-门静脉置入IDDS术者23例。另取行TACE者44例作为对照组。结果:经回肠-门静脉置入IDDS化疗患者全部插管成功,平均操作时间为20min,而TACE平均操作时间为45min。置入IDDS并发症较少且易于处理,较TACE有明显的优越性。结论:经回肠-门静脉置入IDDS化疗较TACE血管堵塞等并发症明显减少,是一种新的、有效的肝肿瘤化疗方法。Objective：To investigate a new method of chemotherapy for hepatoma by implanting implantable drug delivery system （IDDS） through ileum-portal vein. Methods： A total of 157 patients of hepatoma were applied to implant drug delivery system through ileum-portal vein, and the head portion of catheter was set to main portal vein. Among them, 23 cases underwent transcather arterial chemoembolization （TACE） combined with IDDS through ileum-portal vein.Forty-four patients underwent hepatic artery catheterization between Jul, 1999 and Jul, 2003 were assigned as control. Reslts： All the operation of IDDS through ileum-portal vein were successful, average running time was 20 minutes, there were fewer complications and were easily treated. Compared with hepatic artery catheterization, it had conspicuous advantages, Conclsuion： It is a new effective chemotherapy method for hepatoma by ntroducing DDS through i eum-porta vein. It can significantly decrease the clotting of vessel and other complications.

关 键 词：肝肿瘤 门静脉 埋植式给药装置 

分 类 号：R735.7[医药卫生—肿瘤]