普罗布考对动脉粥样硬化性脑梗死并高脂血症患者血脂及预后的影响  

Clinical Investigation on Treating Arteriosclerotic Cerebral Infarction Combined with Hyperlipemia by Prubucol

作　　者：肖卫军 张浩[2] 徐萍蓉[3] 

机构地区：[1]新疆兵团农九师医院,新疆额敏834601 [2]四川省江油市人民医院神经内科,四川成都621700 [3]四川大学华西医院药剂科,四川成都610041

出　　处：《华西医学》2009年第9期2234-2236,共3页West China Medical Journal

摘　　要：目的:探讨普罗布考对动脉粥样硬化性脑梗死并高脂血症患者血脂及预后的影响。方法:将87例脑梗死并高脂血症患者随机分为两组,治疗组44例,对照组43例,两组除按动脉粥样硬化性脑梗死常规治疗外,停用一切降脂药物。治疗组给予普罗布考500 mg bid/d。疗程为6个月。随访一年观察两组患者治疗后血脂水平及脑血管事件发生情况。结果:治疗组患者治疗前、后总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)间差异均有显著性意义(P<0.05)。两组患者治疗后各项血脂指标间差异均有显著性意义(P<0.05)。随访一年,显示治疗组患者心脑血管事件14次,对照组19次(P<0.05)。结论:普罗布考降脂疗效可靠、副作用轻微,降低心脑血管事件发生。可作为动脉粥样硬化性脑梗死并高脂血症患者的一、二级预防药物。Objective： To study the effect of prubucol on the blood liplds level and prognosis in arteriosclerotic cerebral infarction associated with hyperlipidemia patients. Methods： Eighty seven arteriosclerotic cerebral infarction combined with hyperlipidemia patients were randomly divided in to 2 groups： 44 cases in treated group prescribed with prubucol 500 mg bid/day for a course of 6 months. The follow up study lasted forlyear. Observe the changes in blood lipids and the occurrence of acute cardiocerebral vascular event. Results： The level of TC, LDL,TG and HDL increased significantly （P〈0.05）, and the efficacy of treated group was superior to the control group obviously （P〈 0.05）. The results of follow up study showed the numbers of cerebrovascular events in the treatment group were 12 times, and that of the control group were 15 times. Conclusion： Prubucol have curative effect affirmation to treat hy perlipdemia with few side - effect, and reduce the incidence of cerebrovascular diseases and cardiovascular diseases. It should be extended to the clinical use in primary and secondary prevention of arteriosclerotic cerebral infarction combined with hyperlipidemia.

关 键 词：普罗布考 脑梗死 高脂血症 心脑血管病 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R589.2[医药卫生—临床医学]