胃癌浸润转移螺旋CT征象与CD44V6表达  

Spiral CT features of invasion and metastasis and expression of CD44V6 in gastric carcinoma

作　　者：李艳[1] 刘明月[1] 吕传剑[1] 史大鹏[2] 

机构地区：[1]河南省人民医院肿瘤科,郑州450002 [2]河南省人民医院肿瘤科科,郑州450002

出　　处：《医学信息（内.外科版）》2009年第10期926-928,共3页Medical Information Operations Sciences Fascicule

摘　　要：目的探讨胃癌浸润转移螺旋CT(SCT)征象与癌组织中CD44V6表达间的关系。方法对46例胃癌病人行SCT平扫及三期动态增强扫描,术后标本行免疫组化SP法检测CD44V6表达情况,并将SCT征象与CD44V6表达进行对照。结果46例胃癌组织中CD44V6表达率为71.7%(33/46);SCT示胃癌侵犯浆膜、N2站淋巴结转移及远处转移(M1)者CD44V6表达率明显高于浆膜未受侵、N0/N1站淋巴结转移及无远处转移(M0)组(P<0.05)。结论SCT显示的浸润转移征象与CD44V6的表达有关,可用来预测胃癌的浸润和转移。Objective To investigate the correlation of spiral CT（SCT） features of invasion and metastasis with the expression of CD44V6 in Gastric carcinoma （GC）. Methods Plain SCT scan and enhanced triphase SCT scan were performed in 46 patients with pathologically - proved Gastric carcinoma before operation. The specimens were stained with immunohistochemistry to observe the expression of CD44V6. Compare SCT features and expression of CD44V6. Results The expression of CD44V6 in gastric carcinoma was 71.7% （33/46）. The expression of CIN4V6 was significantly higher in gastric carcinoma with serosa infiltration and distant metastasis （M1） and N2 lymph node metastasis than in gastric carcinoma without serosa infiltration and distant metastasis（M0） and N0/N1 lymph node metastasis on SCT features （P 〈 0.05 ）. Conclusions SCT features of invasion and metastasis was closely correlated with expression of CD44V6,which could be a noninvasive method to predict aggressiveness and metastasis in GC.

关 键 词：胃癌 体层摄影术 X线计算机 CD44V6 免疫组织化学 

分 类 号：R73[医药卫生—肿瘤]