Clinical outcomes in patients with ICU-related pancreatitis  

作　　者：Chia-Cheng Tseng Wen-Feng Fang Yu-Hsiu Chung Yi-Hsi Wang Ivor S Douglas Meng-Chih Lin 

机构地区：[1]Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung Hsien 83301, Taiwan. China [2]Department of Respiratory Care, Chang Gung Institute of Technology, Chiayi Hsien 61363, Taiwan, China [3]Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado at Denver and Health Sciences Center, Denver, Colorado, Denver Health Medical Center, Denver 80204, Colorado

出　　处：《World Journal of Gastroenterology》2009年第39期4938-4944,共7页世界胃肠病学杂志（英文版）

摘　　要：AIM:To identify risk factors predictive of intensive care unit(ICU) mortality in patients with ventilator-related pancreatitis.The clinical outcomes of patients with ventilator-related pancreatitis were compared with those of patients with pancreatitis-related respiratory failure as well as controls.METHODS:One hundred and forty-eight patients with respiratory failure requiring mechanical ventilation and concomitant acute pancreatitis were identified from a prospectively collected dataset of 9108 consecutive patients admitted with respiratory failure over a period of five years.Sixty patients met the criteria for ventilator-related pancreatitis,and 88(control patients),for pancreatitis-related respiratory failure.RESULTS:Mortality rate in ventilator-related pancreatitis was comparable to that in ICU patients without pancreatitis by case-control methodology(P=0.544).Multivariate logistic regression analysis identified low PaO2/FiO2(OR:1.032,95% CI:1.006-1.059,P=0.016) as an independent risk factor for mortality in patients with ventilator-related pancreatitis.The mortality rate in patients with ventilator-related pancreatitis was lower than that in patients with acute pancreatitis-related respiratory failure(P<0.001).CONCLUSION:We found that low PaO2/FiO2 was an independent clinical parameter predictive of ICU mortality in patients with ventilator-related pancreatitis.AIM： To identify risk factors predictive of intensive care unit （ICU） mortality in patients with ventilatorrelated pancreatitis. The clinical outcomes of patients with ventilator-related pancreatitis were compared with those of patients with pancreatitis-related respiratory failure as well as controls. METHODS： One hundred and forty-eight patients with respiratory failure requiring mechanical ventilation and concomitant acute pancreatitis were identified from a prospectively collected dataset of 9108 consecutive patients admitted with respiratory failure over a period of five years. Sixty patients met the criteria for ventilator-related pancreatitis, and 88 （control patients）, for pancreatitis-related respiratory failure. RESULTS： Mortality rate in ventilator-related pancreatitis was comparable to that in ICU patients without pancreatitis by case-control methodology （P = 0.544）. Multivariate logistic regression analysis identified low PaO2/FiO2 （OR： 1.032, 95% CI： 1.006-1.059, P = 0.016） as an independent risk factor for mortality in patients with ventilator-related pancreatitis. The mortality rate in patients with ventilator-related pancreatitis was lower than that in patients with acute pancreatitis-related respiratory failure （P 〈 0.001）. CONCLUSION： We found that low PaO2/FiO2 was an independent clinical parameter predictive of ICU mortality in patients with ventilator-related pancreatitis.

关 键 词：Acute pancreatitis HYPERAMYLASEMIA Hyperlipasemia Mechanical ventilation Respiratory failure 

分 类 号：R576[医药卫生—消化系统]