^(18)F-FDG PET/CT多时间点显像鉴别良恶性病变的实验研究  

An experimental study of ^(18)F-FDG PET/CT multi-time point imaging for differentiating tumor from inflammation

作　　者：刘军[1] 张彩霞[1] 

机构地区：[1]中国医科大学盛京医院核医学科,辽宁沈阳110004

出　　处：《中国临床医学影像杂志》2009年第10期746-749,754,共5页Journal of China Clinic Medical Imaging

摘　　要：目的:通过对Wistar鼠肿瘤与炎症模型行18F-FDG PET/CT多个时间点静态采集,获得各时间点的SUVmax,结合葡萄糖转运蛋白1(Glut1)表达鉴别病变良恶性。方法:肿瘤组鼠于右腋窝皮下注射wk256细胞悬液;炎症组鼠于左下肢近腹股沟处肌肉注射松节油。每只模型鼠分别在注药(FDG)后第20、40、60、80、100及120min行PET/CT采集,测其SUVmax。显像结束后取材行病理和免疫组化分析。结果:两组SUVmax随时间延长均增加,在第100min时有统计学意义(t=2.59,P<0.05);如以第40min作为早期显像,计算两组各个时间点的SUVmax与其第40min的SUVmax的比值(IR40),在第80min即有统计学意义(t=3.45,P<0.01)。肿瘤组的Glut1表达(12.67±3.25)高于炎症组(7.18±1.52)(P<0.05);肿瘤组第80min SUVmax及RI与Glut1正相关(r1=0.69,P<0.05;r2=0.86,P<0.001),炎症组第80min SUVmax与Glut1正相关(r=0.61,P<0.05),RI与Glut1无相关性(r=0.57,P>0.05)。结论:肿瘤随时间延长摄取FDG程度高于炎症,可能与肿瘤的Glut1表达明显高于炎症有关;肿瘤与炎症的FDG摄取均与Glut1正相关;RI较单次SUVmax更好地鉴别良恶性病变,并且通过适当延迟显像能较单次采集缩短了整个过程的检查时间。Objective： To investigate SUVmax and Glut1 for the differentiation of tumor from inflammation using ^18F-FDG multi-time point imaging obtained by PET/CT scanner in animal models. Materials and Methods： Tumor group rats were subcutanceously injected wk256 into fight oxter, inflammation group rats were intramuscularly injected turpentine into left hind leg. Each animal model was scanned at 20, 40, 60, 80, 100, 120min after FDG injection, SUVmax was measured. HE and immunohistochemistry were analysed for lesions. Results： FDG accumulation of the two groups increased with time, they had a significant difference at 100min （t=2.59, P〈0.05）; with the early image acquired at 40min, calculated IR40 （SUVmax at every time point divided by the SUVmax at 40min）, they had a significant difference from 80min （t=3.45, P〈0.01）. The Glut1 was significantly higher in the tumor （12.67±3.25） than inflammation （7.18±1.52）（P〈0.05）; The SUVmax of 80min and RI in tumors had positive correlation with Glut1 （r1=0.69, P〈0.05; r2=0.86, P〈0.001）. The SUVmax of 80min in inflammation had positive correlation with Glut1 （r=0.61, P〈0.05）, RI had no correlation with Glut1 （r=0.57, P〉0.05）. Conclusion： The higher Glut1 expression level in the tumor may partially explain the higher FDG accumulation in the tumor than inflammation. FDG of two groups had positive correlation with Glut1, RI was better than SUVmax for differentiating lesions. The proper delayed imaging could shorten the overall testing time rather than single-time-point imaging.

关 键 词：肿瘤 实验性 大鼠 Wistar 放射性核素显像 

分 类 号：R73-354[医药卫生—肿瘤] R817.4[医药卫生—临床医学]