一氧化氮作为高血压大鼠卒中前状态分子标志物研究  

Study of Nitric Oxide as Molecular Marker of Prestroke State in Hypertensive Rats

作　　者：张平[1] 聂亚雄[2] 张新华[1] 刘淑云[1] 陈勇军[1] 蒋福生[1] 

机构地区：[1]南华大学附属南华医院神经内科,湖南省衡阳市421002 [2]南华大学附属第一医院神经内科,湖南省衡阳市421001

出　　处：《中国动脉硬化杂志》2009年第8期677-679,共3页Chinese Journal of Arteriosclerosis

摘　　要：目的观察易卒中型肾血管性高血压大鼠在经历人工寒潮卒中前血浆一氧化氮含量差异,从而探讨一氧化氮能否作为卒中前状态分子标志物。方法双肾双夹法制作易卒中型肾血管性高血压大鼠模型,经历人工寒潮并于寒潮前及寒潮结束时取血,硝酸还原酶法检测血浆一氧化氮含量。结果脑梗死组和脑出血组寒潮前一氧化氮含量明显低于非卒中组,且脑梗死组和脑出血组寒潮后的一氧化氮含量明显低于寒潮前。结论一氧化氮有可能成为卒中前状态分子标志物之一。Aim To investigate changes of serum nitric oxide（NO） in stroke-prone renovascular hypertensive rats（RHRSP） before artificicial cold.To explore the possibility of nitric oxide used as the prediction index of stroke. Methods Two-kidney,two-clip methods were used to copy the model of renovascular hypertension in rats,Serum NO levels were measured by nitrate reductase before and after artificicial cold. Results Serum NO levels in cerebral infarction group and cerebral hemorrhage group were significantly lower than that in the non-stroke group before artificicial cold;serum NO levels in cerebral infarction group and cerebral hemorrhage group after artificicial cold were significantly lower than that before artificicial cold. Conclusion Serum NO could be used as the prediction index of stroke.

关 键 词：脑卒中 易卒中肾血管性高血压大鼠 一氧化氮 人工寒潮 分子标志物 

分 类 号：R741[医药卫生—神经病学与精神病学]